Associations of CYP2A6 genotype with smoking behaviors in southern China.
Associations of CYP2A6 genotype with smoking behaviors in southern China.
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DOI：
10.1111/j.1360-0443.2010.03353.x
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发表时间：
2011-05
期刊：
影响因子：
--
通讯作者：
Chen WQ
中科院分区：
文献类型：
--
作者：
Liu T;David SP;Tyndale RF;Wang H;Zhou Q;Ding P;He YH;Yu XQ;Chen W;Crump C;Wen XZ;Chen WQ
探讨中国吸烟者CYP2A6基因多态性与吸烟相关表型的关联。仅病例遗传关联研究。华南地区 2006 年至 2007 年，共有 1,328 名汉族吸烟者参加了广州和珠海的社区慢性病筛查项目。所有参与者均回答了有关社会人口状况和吸烟行为的结构化问卷，并对细胞色素 P450 2A6 (CYP2A6) 基因 (CYP2A6 *4、*5、*7、*9 和 *10) 的信息等位基因进行了基因分型。 CYP2A6 *4、*5、*7、*9 和 *10 等位基因的频率分别为 8.5%、1.2%、6.3%、13.5% 和 2.4%，分别对应于正常代谢者、中代谢者、慢代谢者和弱代谢者的 48.9%、15.4%、24.2% 和 11.5%。多变量分析表明，与正常代谢者相比，代谢不良者报告每天吸烟较少（调整后 OR = 0.49；95% CI：0.32–0.76），在晚年开始定期吸烟（调整后 OR = 1.55；95% CI：1.06–2.26），并且在以前吸烟者中，报告戒烟前吸烟时间较短（调整后 OR = 0.33；95% CI：0.12-0.94）。然而，代谢较差的人比代谢正常的人戒烟和保持戒烟的可能性更小（OR = 0.54；95% CI：0.34–0.86）。吸烟者 CYP2A6 代谢功能的降低似乎与吸烟量减少、开始定期吸烟的时间较晚、吸烟持续时间较短以及戒烟可能性较低有关。
To investigate the association of CYP2A6 genetic polymorphisms with smoking-related phenotypes in Chinese smokers. Case-only genetic association study. Southern China A total of 1,328 Han Chinese smokers who participated in a community-based chronic disease screening project in Guangzhou and Zhuhai from 2006 to 2007. All participants were answered a structured questionnaire about socio-demographic status and smoking behaviors and informative alleles for the cytochrome P450 2A6 (CYP2A6) gene (CYP2A6 *4, *5, *7, *9 and *10) were genotyped. The frequencies of CYP2A6 *4, *5, *7, *9 and *10 alleles were 8.5%, 1.2%, 6.3%, 13.5% and 2.4%, which corresponded to 48.9%, 15.4%, 24.2% and 11.5% of participants being classified as normal, intermediate, slow and poor metabolizers, respectively. Multivariate analyses demonstrated that compared with normal metabolizers, poor metabolizers reported smoking fewer cigarettes per day (adjusted OR = 0.49; 95% CI: 0.32–0.76), started smoking regularly later in life (adjusted OR = 1.55; 95% CI: 1.06–2.26) and, amongst former smokers, reported smoking for a shorter duration prior to quitting (adjusted OR = 0.33; 95% CI: 0.12–0.94). However, poor metabolizers were less likely to quit smoking and remain abstinent than normal metabolizers (OR = 0.54; 95% CI: 0.34–0.86). Reduced metabolism function of CYP2A6 in smokers appears to be associated with fewer cigarettes smoked, later initiation of smoking regularly, shorter smoking duration and lower likelihood of smoking cessation.
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DOI：
10.1093/jnci/94.2.108
发表时间：
2002-01-16
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
Benowitz, NL;Pérez-Stable, EJ;Jacob, P
通讯作者：
Jacob, P
影响因子：
8
作者：
Audrain-McGovern, Janet;Al Koudsi, Nael;Tyndale, Rachel F.
通讯作者：
Tyndale, Rachel F.
影响因子：
4.7
作者：
Hyland, Andrew;Higbee, Cheryl;Cummings, K. Michael
通讯作者：
Cummings, K. Michael
影响因子：
2.6
作者：
Ho, Man Ki;Mwenifumbo, Jill C.;Tyndale, Rachel F.
通讯作者：
Tyndale, Rachel F.
影响因子：
2.5
作者：
Kohrman, Matthew
通讯作者：
Kohrman, Matthew