HAPPI-2: a Comprehensive and High-quality Map of Human Annotated and Predicted Protein Interactions.
HAPPI-2: a Comprehensive and High-quality Map of Human Annotated and Predicted Protein Interactions.
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DOI：
10.1186/s12864-017-3512-1
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发表时间：
2017-02-17
期刊：
影响因子：
4.4
通讯作者：
Nguyen TM
中科院分区：
文献类型：
--
作者：
Chen JY;Pandey R;Nguyen TM
人类蛋白质-蛋白质相互作用（PPI）数据对网络和系统生物学研究至关重要。PPI数据可以帮助生化学家假设蛋白质如何通过相互结合形成复合物，细胞外信号如何通过失活信号分子的翻译后修饰传播，以及化学反应如何通过参与复杂生物过程的酶偶联。我们是否有能力为人类PPI数据开发良好的公共数据库资源，直接影响到未来基因组生物学和医学研究的质量。人类注释和预测蛋白质相互作用数据库（HAPPI） 2.0版本是对原来的HAPPI 1.0数据库的重大更新。它包含2,922202个独特的蛋白质蛋白质相互作用（PPI），由23,060个人类蛋白质连接，使其成为当今涵盖人类PPI数据的最全面的数据库。这些ppi既包含物理/直接相互作用，也包含高质量的功能/间接相互作用。与HAPPI 1.0数据库版本相比，HAPPI数据库2.0版本（HAPPI-2）代表了人类PPI数据覆盖率增加了485%，蛋白质覆盖率增加了73%。改进后的HAPPI门户网站为用户提供了友好的搜索、管理和数据检索界面，允许他们检索人类ppi和有关交互类型、交互质量、交互伙伴药物靶向数据和疾病信息的可用注释信息。更新后的HAPPI-2可由学术用户在http://discovery.informatics.uab.edu/HAPPI免费访问。虽然HAPPI-2的基础数据来自不同的数据源，但新的HAPPI-2版本在人类ppi的数据覆盖范围和数据质量之间取得了很好的平衡，使其非常适合网络生物学。本文的在线版本（doi:10.1186/s12864-017-3512-1）包含补充材料，可供授权用户使用。
Human protein-protein interaction (PPI) data is essential to network and systems biology studies. PPI data can help biochemists hypothesize how proteins form complexes by binding to each other, how extracellular signals propagate through post-translational modification of de-activated signaling molecules, and how chemical reactions are coupled by enzymes involved in a complex biological process. Our capability to develop good public database resources for human PPI data has a direct impact on the quality of future research on genome biology and medicine. The database of Human Annotated and Predicted Protein Interactions (HAPPI) version 2.0 is a major update to the original HAPPI 1.0 database. It contains 2,922,202 unique protein-protein interactions (PPI) linked by 23,060 human proteins, making it the most comprehensive database covering human PPI data today. These PPIs contain both physical/direct interactions and high-quality functional/indirect interactions. Compared with the HAPPI 1.0 database release, HAPPI database version 2.0 (HAPPI-2) represents a 485% of human PPI data coverage increase and a 73% protein coverage increase. The revamped HAPPI web portal provides users with a friendly search, curation, and data retrieval interface, allowing them to retrieve human PPIs and available annotation information on the interaction type, interaction quality, interacting partner drug targeting data, and disease information. The updated HAPPI-2 can be freely accessed by Academic users at http://discovery.informatics.uab.edu/HAPPI. While the underlying data for HAPPI-2 are integrated from a diverse data sources, the new HAPPI-2 release represents a good balance between data coverage and data quality of human PPIs, making it ideally suited for network biology. The online version of this article (doi:10.1186/s12864-017-3512-1) contains supplementary material, which is available to authorized users.
影响因子：
3
作者：
Hahn A;Rahnenführer J;Talwar P;Lengauer T
通讯作者：
Lengauer T