Confirmation of human protein interaction data by human expression data.
Confirmation of human protein interaction data by human expression data.
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DOI：
10.1186/1471-2105-6-112
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发表时间：
2005-05-06
影响因子：
3
通讯作者：
Lengauer T
中科院分区：
文献类型：
--
作者：
Hahn A;Rahnenführer J;Talwar P;Lengauer T
利用微阵列技术，可以同时测量数千个基因的表达。众所周知，在酿酒酵母中，相互作用蛋白质的基因的表达水平比不相互作用的蛋白质的基因的表达水平显著更强地相关。这项工作的目的是调查这种观察是否延伸到人类基因组。我们研究了编码相互作用蛋白质的基因和编码随机蛋白质对的基因的表达水平之间的定量关系。因此，我们研究了1369个相互作用的人类蛋白质对和155个阵列的人类基因表达水平。与随机蛋白质对相比，我们能够在其蛋白质相互作用的基因的表达水平之间建立统计学显著更高的相关性。此外，我们能够提供证据表明编码属于相同GO类的蛋白质的基因显示相关的表达水平。这一发现与天真的假设是一致的，即相互作用蛋白质的生产规模是相互联系的，因为有效的相互作用要求所涉及的蛋白质在某种程度上是可用的。这一领域进一步研究的目标将是了解这一观察结果背后的生物学机制。
With microarray technology the expression of thousands of genes can be measured simultaneously. It is well known that the expression levels of genes of interacting proteins are correlated significantly more strongly in Saccharomyces cerevisiae than those of proteins that are not interacting. The objective of this work is to investigate whether this observation extends to the human genome. We investigated the quantitative relationship between expression levels of genes encoding interacting proteins and genes encoding random protein pairs. Therefore we studied 1369 interacting human protein pairs and human gene expression levels of 155 arrays. We were able to establish a statistically significantly higher correlation between the expression levels of genes whose proteins interact compared to random protein pairs. Additionally we were able to provide evidence that genes encoding proteins belonging to the same GO-class show correlated expression levels. This finding is concurrent with the naive hypothesis that the scales of production of interacting proteins are linked because an efficient interaction demands that involved proteins are available to some degree. The goal of further research in this field will be to understand the biological mechanisms behind this observation.
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影响因子：
13.6
作者：
Gröne, HJ;Cohen, CD;Nelson, PJ
通讯作者：
Nelson, PJ
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Zhao, HJ;Whitfield, ML;Brooks, JD
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Brooks, JD
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作者：
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通讯作者：
Grigoriev, A