Directed Connectivity Analysis of the Neuro-Cardio- and Respiratory Systems Reveals Novel Biomarkers of Susceptibility to SUDEP.
Directed Connectivity Analysis of the Neuro-Cardio- and Respiratory Systems Reveals Novel Biomarkers of Susceptibility to SUDEP.
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DOI：
10.1109/ojemb.2020.3036544
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发表时间：
2020
影响因子：
5.8
通讯作者：
Iasemidis L
中科院分区：
文献类型：
--
作者：
Hutson TN;Rezaei F;Gautier NM;Indumathy J;Glasscock E;Iasemidis L
癫痫猝死（SUDEP）是癫痫相关死亡的主要原因，其病理生理机制尚不清楚。目标：我们首次记录和分析来自对照（WT -野生型）和SUDEP易感小鼠（KO-敲除Kcna 1动物模型）的并发脑电图（EEG）、心电图（ECG）和无限制的全身体积描记（Pleth）信号。研究方法：采用多变量自回归模型（MVAR），我们测量了所有的三器官有效的方向相互作用的广义偏定向相干（GPDC）在频域随时间（小时）。结果如下：与对照（WT）动物相比，SUDEP易感（KO）动物表现出（p < 0.001）在全频谱（0- 200 Hz）上减少心脏和大脑之间的传入和传出相互作用，在高频率（>90 Hz）下增强从大脑到肺和从心脏到肺的传出相互作用（特别是在癫痫发作活动期间），以及在低频率（<40 Hz）下从肺到大脑的反馈减少。结论：这些结果表明，在整体神经-心脏-呼吸网络中的传入和传出通路的损伤可能导致SUDEP，有效的连接措施及其动力学可以分别作为SUDEP和癫痫发作易感性的新生物标志物。
Sudden unexpected death in epilepsy (SUDEP) is the leading cause of epilepsy-related mortality and its pathophysiological mechanisms remain unknown. Goal: We set to record and analyze for the first time concurrent electroencephalographic (EEG), electrocardiographic (ECG), and unrestrained whole-body plethysmographic (Pleth) signals from control (WT - wild type) and SUDEP-prone mice (KO- knockout Kcna1 animal model). Methods: Employing multivariate autoregressive models (MVAR) we measured all tri-organ effective directional interactions by the generalized partial directed coherence (GPDC) in the frequency domain over time (hours). Results: When compared to the control (WT) animals, the SUDEP-prone (KO) animals exhibited (p < 0.001) reduced afferent and efferent interactions between the heart and the brain over the full frequency spectrum (0-200Hz), enhanced efferent interactions from the brain to the lungs and from the heart to the lungs at high (>90 Hz) frequencies (especially during periods with seizure activity), and decreased feedback from the lungs to the brain at low (<40 Hz) frequencies. Conclusions: These results show that impairment in the afferent and efferent pathways in the holistic neuro-cardio-respiratory network could lead to SUDEP, and effective connectivity measures and their dynamics could serve as novel biomarkers of susceptibility to SUDEP and seizures respectively.
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DOI：
10.1016/j.yebeh.2013.09.019
发表时间：
2014-09
期刊：
Epilepsy & behavior : E&B
影响因子：
--
作者：
Glasscock E
通讯作者：
Glasscock E
DOI：
10.1152/ajpheart.00782.2009
发表时间：
2010-01-01
影响因子：
4.8
作者：
Fu, Liang-Wu;Longhurst, John C.
通讯作者：
Longhurst, John C.
影响因子：
8
作者：
Good LB;Sabesan S;Marsh ST;Tsakalis K;Treiman D;Iasemidis L
通讯作者：
Iasemidis L
影响因子：
5.3
作者：
Dlouhy, Brian J.;Gehlbach, Brian K.;Richerson, George B.
通讯作者：
Richerson, George B.
影响因子：
2.2
作者：
Chaovalitwongse, W;Lasemidis, LD;Sackellares, JC
通讯作者：
Sackellares, JC