Impact of metabolism-related mutations on the heart rate of gastric cancer patients after peritoneal lavage.
Impact of metabolism-related mutations on the heart rate of gastric cancer patients after peritoneal lavage.
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DOI：
10.12998/wjcc.v9.i6.1318
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发表时间：
2021-02-26
影响因子：
1.1
通讯作者：
Zhang XY
中科院分区：
文献类型：
--
作者：
Yuan Y;Yao S;Luo GH;Zhang XY
在胃癌手术期间，使用温蒸馏水进行腹腔灌洗可引起暂时的血流动力学变化。研究心率变化与单核苷酸多态性（SNPs）之间的关系。这是一项前瞻性观察性研究，研究对象为2018年3月至2019年3月在苏州大学附属第三医院接受胃切除术和腹膜低渗灌洗的胃癌患者。选择相关SNP，并分析验证的外显子。灌洗前后测量心率和血压。按心率变化≥ 30%和<30%分组。对两组SNPs进行比较和回归分析。 根据纳入/排除标准，194例患者纳入分析。这些患者中，138例为男性，平均年龄为65.9 ± 0.8岁，56例为女性，平均年龄为65.0 ± 1.3岁。65名参与者的心率下降了0%-10%，29人下降了10%-15%，23人下降了15%-20%，39人下降了20%-50%，4人下降了50%-100%，6人心脏骤停，28人心率增加。考虑到外显子SNP对表型的可能影响，分析了TEP 1（rs 938886）、TEP 1（rs 1713449）和RECQL 5（rs 820196）。单倍型分析表明，单倍型CTT [比值比（OR）= 2.018，95%置信区间（CI）：1.012-4.025，P = 0.0430]和GCC TEP 1（rs 938886）、TEP 1（rs 1713449）和RECQL 5（rs 820196）的OR = 2.293，95%CI：1.174-4.477，P = 0.0131，增加心率下降> 30%的风险。TEP 1（rs 938886）、TEP 1（rs 1713449）和RECQL 5（rs 820196）SNP与胃癌切除术后使用蒸馏水腹腔灌洗期间心率变化≥ 30%相关。
During surgery for gastric cancer, peritoneal lavage using warm distilled water can cause temporary hemodynamic changes. To examine the associations between changes in heart rate and single nucleotide polymorphisms (SNPs). This was a prospective observational study of patients with gastric cancer who underwent gastrectomy and peritoneal hypotonic lavage at the Third Affiliated Hospital of Soochow University from March 2018 to March 2019. Related SNPs were selected, and the verified exons were analyzed. Heart rate and blood pressure (BP) were measured before and after lavage. The patients were grouped as heart rate change ≥ 30% vs < 30%. Comparison and regression analyses of the selected SNPs were performed between the two groups. According to the inclusion/exclusion criteria, 194 patients were included in the analysis. Of these patients, 138 were male, with a mean age of 65.9 ± 0.8 years, and 56 were female, with a mean age of 65.0 ± 1.3 years. Heart rate dropped by 0%-10% in 65 participants, by 10%-15% in 29, by 15%-20% in 23, by 20%-50% in 39, by 50%-100% in four, six had a cardiac arrest, and 28 had an increase in heart rate. Considering the possible impact of exonic SNPs on the phenotypes, TEP1 (rs938886), TEP1 (rs1713449), and RECQL5 (rs820196) were analyzed. The haplotype analysis suggested that the haplotypes CTT [odds ratio (OR) = 2.018, 95% confidence interval (CI): 1.012-4.025, P = 0.0430] and GCC (OR = 2.293, 95%CI: 1.174-4.477, P = 0.0131) of TEP1 (rs938886), TEP1 (rs1713449), and RECQL5 (rs820196) increased the risk of a drop in heart rate > 30%. The TEP1 (rs938886), TEP1 (rs1713449), and RECQL5 (rs820196) SNPs were associated with changes in heart rate ≥ 30% during intraperitoneal lavage using distilled water after gastrectomy for gastric cancer.
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影响因子：
82.9
作者：
通讯作者：
--
DOI：
10.1073/pnas.0308710100
发表时间：
2004-03-02
影响因子：
11.1
作者：
Hansson, A;Hance, N;Larsson, NG
通讯作者：
Larsson, NG
影响因子：
4.8
作者：
Kickhoefer, VA;Stephen, AG;Rome, LH
通讯作者：
Rome, LH
影响因子：
50.5
作者：
Smyth, E. C.;Verheij, M.;Arnold, D.
通讯作者：
Arnold, D.
影响因子：
7.4
作者：
Ohki, Atsuko;Abe, Nobutsugu;Sugiyama, Masanori
通讯作者：
Sugiyama, Masanori