Microenvironmental regulation of tumor progression and metastasis.
Microenvironmental regulation of tumor progression and metastasis.
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癌症在复杂的组织环境中发展，它们依赖于这种环境进行持续的生长、侵袭和转移。与肿瘤细胞不同，肿瘤微环境（TME）中的基质细胞类型在遗传上是稳定的，因此是一种具有较低耐药性和肿瘤复发风险的有吸引力的治疗靶点。然而，具体破坏促肿瘤TME是一项具有挑战性的工作，因为TME具有诱导肿瘤发生的有利和不利后果的多种能力。此外，许多研究表明，微环境能够使肿瘤细胞正常化，这表明基质细胞的再教育，而不是靶向消融本身，可能是治疗癌症的有效策略。在这里，我们将讨论TME在癌症进展和转移的特定阶段的矛盾作用，以及最近在TME内重新教育基质细胞以具有抗致瘤作用的治疗尝试。
Cancers develop in complex tissue environments, which they depend upon for sustained growth, invasion and metastasis. Unlike tumor cells, stromal cell types within the tumor microenvironment (TME) are genetically stable, and thus represent an attractive therapeutic target with reduced risk of resistance and tumor recurrence. However, specifically disrupting the pro-tumorigenic TME is a challenging undertaking, as the TME has diverse capacities to induce both beneficial and adverse consequences for tumorigenesis. Furthermore, many studies have shown that the microenvironment is capable of normalizing tumor cells, suggesting that reeducation of stromal cells, rather than targeted ablation per se, may be an effective strategy for treating cancer. Here, we will discuss the paradoxical roles of the TME during specific stages of cancer progression and metastasis, and recent therapeutic attempts to re-educate stromal cells within the TME to have anti-tumorigenic effects.
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影响因子：
4.4
作者：
Almand, B;Clark, JI;Gabrilovich, DI
通讯作者：
Gabrilovich, DI
影响因子：
3
作者：
Brown, KM;Domin, C;Shoup, M
通讯作者：
Shoup, M
影响因子：
2.7
作者：
Chaffer, Christine L.;Thompson, Erik W.;Williams, Elizabeth D.
通讯作者：
Williams, Elizabeth D.
分子机制和血管生成的临床应用。
影响因子：
64.8
作者：
Carmeliet, Peter;Jain, Rakesh K.
通讯作者：
Jain, Rakesh K.
影响因子：
28.2
作者：
Catena R;Bhattacharya N;El Rayes T;Wang S;Choi H;Gao D;Ryu S;Joshi N;Bielenberg D;Lee SB;Haukaas SA;Gravdal K;Halvorsen OJ;Akslen LA;Watnick RS;Mittal V
通讯作者：
Mittal V