The intersection of host and fungus through the zinc lens.
The intersection of host and fungus through the zinc lens.
复制标题
宿主和真菌通过锌透镜的交叉点。
DOI：
10.1016/j.mib.2019.04.008
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发表时间：
2019
影响因子：
5.4
通讯作者：
DeepeJr,GeorgeS
中科院分区：
文献类型：
--
作者：
Wilson,Duncan;DeepeJr,GeorgeS
钙卫蛋白是一种剥夺真菌胞外锌的关键蛋白，另外两种S100A分子从真菌中螯合锌。本文综述了锌对宿主防御人类病原真菌的影响以及真菌如何获得锌以维持其生物学功能。哺乳动物已经进化出几种细胞外和细胞内机制来阻止锌从真菌。特异性免疫细胞释放锌结合蛋白，如钙卫蛋白，以捕获金属并将其拒绝给真菌。在细胞内，几种锌结合蛋白如金属硫蛋白使真菌缺乏锌。这两种情况的最终结果都是剥夺了真菌的一种关键微量营养素。为了对抗这场斗争，真菌已经开发出捕获锌并储存锌的方法。本文讨论了各种真菌的运输机制。
HighlightsCalprotectin is a key protein that deprives extracellular fungi of zinc.Two other S100A molecules sequester zinc from fungi.Upregulation of metallothioneins by GM-CSF deprives H. capsulatum of zinc in the phagosome.All studied human pathogenic fungi have zinc transporters that capture this metal from the environment and contribute to pathogenicity.Many fungi possess a zincophore that is instrumental in zinc scavenging in neutral/alkaline environments.In this review, we summarize data regarding the influence of zinc on host defenses to human pathogenic fungi and how the fungus acquires zinc to sustain biological functions. Mammals have evolved several extracellular and intracellular mechanisms to withhold zinc from the fungus. Specific immune cells release zinc binding proteins such as calprotectin to capture the metal and deny it to the fungus. Intracellularly, several zinc binding proteins such as metallothioneins starve the fungus of zinc. The net result in both situations is depriving the fungus of a crucial micronutrient. To combat this struggle, fungi have developed means to capture zinc and store it. The mechanisms of transport for various fungi are discussed herein.
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影响因子：
32.4
作者：
Subramanian Vignesh K;Landero Figueroa JA;Porollo A;Caruso JA;Deepe GS Jr
通讯作者：
Deepe GS Jr
影响因子：
5.6
作者：
Lehtovirta-Morley LE;Alsarraf M;Wilson D
通讯作者：
Wilson D
白色念珠菌分泌的 pH 调节抗原 1 阻断补体 C3 的激活和转化
影响因子：
4.4
作者：
Shanshan Luo;A. Hartmann;H. Dahse;C. Skerka;P. Zipfel
通讯作者：
P. Zipfel
白色念珠菌中环 AMP 途径激活和细胞外锌诱导细胞内锌快速动员
影响因子：
5.2
作者：
L. Kjellerup;A. M. Winther;Duncan W. Wilson;A. Fuglsang
通讯作者：
A. Fuglsang
影响因子：
16.6
作者：
Zygiel EM;Nolan EM
通讯作者：
Nolan EM