The origins of sexually transmitted HIV among men who have sex with men.
The origins of sexually transmitted HIV among men who have sex with men.
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DOI：
10.1126/scitranslmed.3000447
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发表时间：
2010-02-10
影响因子：
17.1
通讯作者：
Smith DM
中科院分区：
文献类型：
--
作者：
Butler DM;Delport W;Kosakovsky Pond SL;Lakdawala MK;Cheng PM;Little SJ;Richman DD;Smith DM
虽然已知世界上大多数HIV-1感染是由于暴露于精液中的病毒引起的，但尚未确定传播株是起源于精浆中的RNA病毒粒子，还是起源于受感染的精液白细胞中的整合前病毒DNA。我们提出的系统发育证据表明，在六对男男性行为传播的男性中，受体的血浆病毒与源的精液病毒始终更密切相关。所有序列均为B亚型，传播变异的env C2V3倾向于具有更高的平均等电点，包含潜在的n链糖基化位点，并且有利于CCR5共受体的使用。一项统计上可靠的系统发育校正分析并没有检测到与传播相关的遗传特征，但对传播对更大样本的进一步调查有望确定病毒基因组的哪些结构和遗传特征与传播相关。
Although it is known that most HIV-1 infections worldwide result from exposure to virus in semen, it has not yet been established whether transmitted strains originate as RNA virions in seminal plasma or as integrated proviral DNA in infected seminal leukocytes. We present phylogenetic evidence that among six transmitting pairs of men who have sex with men, blood plasma virus in the recipient is consistently more closely related to the seminal plasma virus in the source. All sequences were subtype B, and the env C2V3 of transmitted variants tended to have higher mean isoelectric points, contain potential N-linked glycosylation sites, and favor CCR5 co-receptor usage. A statistically robust phylogenetically corrected analysis did not detect genetic signatures reliably associated with transmission, but further investigation of larger samples of transmitting pairs holds promise for determining which structural and genetic features of viral genomes are associated with transmission.
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影响因子：
4.3
作者：
Kosakovsky Pond SL;Posada D;Stawiski E;Chappey C;Poon AF;Hughes G;Fearnhill E;Gravenor MB;Leigh Brown AJ;Frost SD
通讯作者：
Frost SD
影响因子：
56.3
作者：
Boily, Marie-Claude;Baggaley, Rebecca F.;Wang, Lei;Masse, Benoit;White, Richard G.;Hayes, Richard J.;Alary, Michel
通讯作者：
Alary, Michel
影响因子：
5.8
作者：
Pond, Sergei L. Kosakovsky;Posada, David;Frost, Simon D. W.
通讯作者：
Frost, Simon D. W.
DOI：
10.1073/pnas.0804192105
发表时间：
2008-10-28
影响因子：
11.1
作者：
Joos, Beda;Fischer, Marek;Guenthard, Huldrych F.
通讯作者：
Guenthard, Huldrych F.
影响因子：
9.8
作者：
Drummond AJ;Ho SY;Phillips MJ;Rambaut A
通讯作者：
Rambaut A