SCORE Study report 3: study design and baseline characteristics.
SCORE Study report 3: study design and baseline characteristics.
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DOI：
10.1016/j.ophtha.2009.03.022
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发表时间：
2009-09
期刊：
影响因子：
13.7
通讯作者：
SCORE Study Investigator Group
中科院分区：
文献类型：
--
作者：
Ip MS;Oden NL;Scott IU;VanVeldhuisen PC;Blodi BA;Figueroa M;Antoszyk A;Elman M;SCORE Study Investigator Group
描述标准治疗与皮质类固醇治疗视网膜静脉阻塞（SCORE）研究中受试者的基线特征，并与其他视网膜静脉阻塞试验的队列进行比较。还描述了SCORE研究的设计。两项多中心III期随机临床试验，一项涉及视网膜中央静脉阻塞（CRVO）受试者，另一项涉及视网膜分支静脉阻塞（BRVO）受试者。682名参与者，包括271名CRVO和411名BRVO。总结并比较CRVO和BRVO研究受试者的人口统计学和研究眼特征。基线眼科特征，包括入组前的视力和黄斑水肿持续时间，以及病史特征，包括糖尿病和高血压。在CRVO试验中，基线时，平均视力字母评分为51（1020/100），平均光学相干断层扫描（OCT）测量的中央子场厚度为595微米，彩色摄影黄斑网格中视网膜增厚的平均面积为12.3个椎间盘面积，荧光素渗漏的平均面积为11.0个椎间盘面积。在BRVO试验中，基线时，平均视力字母评分为57（1020/80），OCT测量的平均中心子场厚度为491微米，彩色摄影黄斑网格中视网膜增厚的平均面积为7.5个椎间盘面积，荧光素渗漏的平均面积为6.1个椎间盘面积。在基线视力、OCT测量的视网膜厚度、彩色摄影的视网膜增厚面积和荧光素渗漏面积中观察到的差异支持在单独试验中对CRVO和BRVO的评价。
To describe the baseline characteristics of the participants in the Standard Care versus COrticosteroid for REtinal Vein Occlusion (SCORE) Study and to compare with cohorts from other retinal vein occlusion trials. The design of the SCORE Study is also described. Two multicenter phase 3 randomized clinical trials, one involving participants with central retinal vein occlusion (CRVO) and one involving participants with branch retinal vein occlusion (BRVO). 682 participants, including 271 with CRVO and 411 with BRVO. Demographic and study eye characteristics are summarized and compared between the CRVO and BRVO study participants. Baseline ophthalmic characteristics, including visual acuity and duration of macular edema prior to enrollment, and medical history characteristics, including diabetes mellitus and hypertension. In the CRVO trial, at baseline, mean visual acuity letter score was 51 (∼20/100), mean optical coherence tomography (OCT)-measured central subfield thickness was 595 microns, mean area of retinal thickening in the macular grid on color photography was 12.3 disc areas and mean area of fluorescein leakage was 11.0 disc areas. In the BRVO trial, at baseline, mean visual acuity letter score was 57 (∼20/80), mean OCT-measured central subfield thickness was 491 microns, mean area of retinal thickening in the macular grid on color photography was 7.5 disc areas and the mean area of fluorescein leakage was 6.1 disc areas. Differences observed in baseline visual acuity, OCT-measured retinal thickness, area of retinal thickening on color photography and area of fluorescein leakage support the evaluation of CRVO and BRVO in separate trials.
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影响因子：
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作者：
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通讯作者：
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作者：
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DOI：
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发表时间：
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影响因子：
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作者：
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通讯作者：
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