MACULAR PIGMENT OPTICAL DENSITY IS LOWER IN TYPE 2 DIABETES, COMPARED WITH TYPE 1 DIABETES AND NORMAL CONTROLS
MACULAR PIGMENT OPTICAL DENSITY IS LOWER IN TYPE 2 DIABETES, COMPARED WITH TYPE 1 DIABETES AND NORMAL CONTROLS
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与 1 型糖尿病和正常对照相比，2 型糖尿病的黄斑色素光学密度较低
DOI：
10.1097/iae.0000000000000551
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
J. Loughman
中科院分区：
文献类型：
--
作者：
Grainne Scanlon;P. Connell;Matthew Ratzlaff;Brittany Foerg;D. McCartney;Audrey Murphy;Karen O'Connor;J. Loughman
目的：本研究旨在研究1型和2型糖尿病患者黄斑色素的光密度，并与正常对照组进行比较。研究方法：研究招募了150名受试者，并根据他们的健康状况分为三个研究组之一，如下所示：第1组：健康对照;第2组：1型糖尿病;第3组：2型糖尿病。使用定制的异色闪烁光度法测量视网膜偏心率为0.5°时的黄斑色素光密度。膳食摄入的黄斑类胡萝卜素定量使用叶黄素和玉米黄质食物频率问卷。记录糖尿病类型、病程、药物、吸烟习惯、糖化血红蛋白（HbA 1C）和血脂水平，同时测量每位参与者的视力、体重指数和糖尿病视网膜病变分级。结果如下：单因素方差分析显示，3组间体重指数、年龄、高密度脂蛋白胆固醇和HbA 1C差异有统计学意义（均P < 0.01）。卡方分析显示糖尿病视网膜病变的分布差异有统计学意义（P < 0.01）。在任何研究组中，这些变量均未表现出与黄斑色素光密度的统计学显著相关性（全部P > 0.05）。两组之间的膳食类胡萝卜素摄入量没有差异。2型糖尿病患者的黄斑色素光密度（0.33 ± 0.21）低于1型糖尿病患者（0.49 ± 0.23）和对照组（0.48 ± 0.35）。以年龄、体重指数、糖尿病病程、糖尿病视网膜病变状态、高密度脂蛋白胆固醇和HbA 1C为协变量的一般线性模型分析显示，糖尿病类型对黄斑色素光密度的影响具有统计学意义（F = 2.62; P = 0.04）。结论：与1型糖尿病和正常对照组相比，2型糖尿病患者的黄斑色素光密度在统计学上显著降低。虽然2型糖尿病组的体重指数较高，但2型糖尿病组中观察到的黄斑色素光密度水平较低似乎与饮食类胡萝卜素摄入量的差异或糖尿病的具体存在、糖尿病控制、持续时间或糖尿病视网膜病变无关。
Purpose: This study was designed to investigate the optical density of macular pigment in Type 1 and Type 2 diabetes subjects relative to normal controls. Methods: One hundred and fifty subjects were recruited to the study and divided into one of the three study groups on the basis of their health status, as follows: Group 1: Healthy controls; Group 2: Type 1 diabetes; Group 3: Type 2 diabetes. Macular Pigment Optical Density, at 0.5° of retinal eccentricity, was measured using customized heterochromatic flicker photometry. Dietary intake of macular carotenoids was quantified using a lutein and zeaxanthin food frequency questionnaire. Diabetes type, duration, medication, smoking habits, glycosylated hemoglobin (HbA1C), and serum lipid levels were recorded, whereas visual acuity, body mass index, and diabetic retinopathy grade were measured for each participant. Results: One-way analysis of variance revealed a statistically significant difference in body mass index, age, high-density lipoprotein cholesterol and HbA1C between the three groups (P < 0.01 for all). Chi-square analysis revealed a statistically significant difference in diabetic retinopathy distribution (P < 0.01). None of these variables exhibited a statistically significant correlation with macular pigment optical density for any study group (P > 0.05 for all). There was no difference in dietary carotenoid intake between groups. Macular pigment optical density was lower among Type 2 diabetes subjects (0.33 ± 0.21) compared with Type 1 diabetes (0.49 ± 0.23) and controls (0.48 ± 0.35). General linear model analysis, including age, body mass index, diabetes duration, diabetic retinopathy status, high-density lipoprotein cholesterol, and HbA1C as covariates, revealed a statistically significant effect of diabetes type on macular pigment optical density (F = 2.62; P = 0.04). Conclusion: Macular pigment optical density was statistically significantly lower in Type 2 diabetes compared with Type 1 diabetes and normal controls. Although body mass index was higher in the Type 2 diabetes group, the lower macular pigment optical density levels observed among Type 2 diabetes seem not to be attributable to differences in dietary carotenoid intake or to the specific presence of diabetes, diabetic control, duration, or diabetic retinopathy.
DOI：
10.1093/ajcn/62.6.1448s
发表时间：
1995-12
期刊：
The American journal of clinical nutrition
影响因子：
--
作者：
D. Snodderly
通讯作者：
D. Snodderly
影响因子：
4.4
作者：
R. Bone;J. Landrum;Hime Gw;A. Cains;J. Zamor
通讯作者：
R. Bone;J. Landrum;Hime Gw;A. Cains;J. Zamor
成人囊性纤维化患者的叶黄素、玉米黄质、黄斑色素和视功能。
DOI：
10.1093/ajcn/79.6.1045
发表时间：
2004
期刊：
The American journal of clinical nutrition
影响因子：
--
作者：
Schupp,Christine;Olano-Martin,Estibaliz;Gerth,Christina;Morrissey,BrianM;Cross,CarrollE;Werner,JohnS
通讯作者：
Werner,JohnS