Unilateral Mitochondrial-Hemodynamic Coupling and Bilateral Connectivity in the Prefrontal Cortices of Young and Older Healthy Adults.
Unilateral Mitochondrial-Hemodynamic Coupling and Bilateral Connectivity in the Prefrontal Cortices of Young and Older Healthy Adults.
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年轻和老年健康成人前额叶皮层的单侧线粒体-血流动力学耦合和双侧连接。
DOI：
10.3390/bioengineering10111336
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发表时间：
2023-11-20
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影响因子：
--
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最近的一项研究表明，无创测量皮质血流动力学和代谢在休息的人前额叶皮层可以促进定量指标的单侧脑血流动力学耦合和双边连接在年轻人的低频振荡频率。低频振荡包括内源性（E）、神经性（N）和肌源性（M）频带的三种不同的血管运动。本研究的目的是证明年轻人和老年人在前额叶皮质的单侧耦合（uCOP）和双侧连接（bCON）方面存在显着差异的假设。因此，我们使用与最近研究相同的双通道宽带近红外光谱（bbNIRS）设置和静息状态实验方案对24名老年人（67.2 ± 5.9岁）进行了测量。在三个E/N/M频率下的uCOP和bCON定量和统计分析后，我们证明老年人在M波段的双侧血流动力学连接明显较弱，但双侧代谢连接明显较强。此外，老年人在所有E/N/M波段的双侧前额叶都表现出明显更强的单侧耦合，特别是在M波段的效应量非常大（>1.9）。这些与年龄相关的结果清楚地支持了我们的假设，并根据神经生理学原理得到了很好的解释。本文的关键发现是，uCOP和bCON的神经生理指标与年龄高度相关，可能有潜力成为人类大脑健康的有意义的特征，并可用于未来的临床应用，例如阿尔茨海默病的早期检测。
A recent study demonstrated that noninvasive measurements of cortical hemodynamics and metabolism in the resting human prefrontal cortex can facilitate quantitative metrics of unilateral mitochondrial–hemodynamic coupling and bilateral connectivity in infraslow oscillation frequencies in young adults. The infraslow oscillation includes three distinct vasomotions with endogenic (E), neurogenic (N), and myogenic (M) frequency bands. The goal of this study was to prove the hypothesis that there are significant differences between young and older adults in the unilateral coupling (uCOP) and bilateral connectivity (bCON) in the prefrontal cortex. Accordingly, we performed measurements from 24 older adults (67.2 ± 5.9 years of age) using the same two-channel broadband near-infrared spectroscopy (bbNIRS) setup and resting-state experimental protocol as those in the recent study. After quantification of uCOP and bCON in three E/N/M frequencies and statistical analysis, we demonstrated that older adults had significantly weaker bilateral hemodynamic connectivity but significantly stronger bilateral metabolic connectivity than young adults in the M band. Furthermore, older adults exhibited significantly stronger unilateral coupling on both prefrontal sides in all E/N/M bands, particularly with a very large effect size in the M band (>1.9). These age-related results clearly support our hypothesis and were well interpreted following neurophysiological principles. The key finding of this paper is that the neurophysiological metrics of uCOP and bCON are highly associated with age and may have the potential to become meaningful features for human brain health and be translatable for future clinical applications, such as the early detection of Alzheimer’s disease.
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DOI：
10.1029/jb092ib12p12675
发表时间：
1987-11-10
期刊：
JOURNAL OF GEOPHYSICAL RESEARCH-SOLID EARTH AND PLANETS
影响因子：
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作者：
PARK, J;LINDBERG, CR;VERNON, FL
通讯作者：
VERNON, FL
充血性心力衰竭和β1阻滞治疗后的低频血流振荡。
影响因子：
3.1
作者：
Bernjak, A.;Clarkson, P. B. M.;McClintock, P. V. E.;Stefanovska, A.
通讯作者：
Stefanovska, A.
影响因子：
3
作者：
Bastos AM;Schoffelen JM
通讯作者：
Schoffelen JM
影响因子：
5.7
作者：
Bainbridge A;Tachtsidis I;Faulkner SD;Price D;Zhu T;Baer E;Broad KD;Thomas DL;Cady EB;Robertson NJ;Golay X
通讯作者：
Golay X
影响因子：
5.3
作者：
Li L;Babawale O;Yennu A;Trowbridge C;Hulla R;Gatchel RJ;Liu H
通讯作者：
Liu H