Low-frequency blood flow oscillations in congestive heart failure and after beta1-blockade treatment.
Low-frequency blood flow oscillations in congestive heart failure and after beta1-blockade treatment.
复制标题
充血性心力衰竭和β1阻滞治疗后的低频血流振荡。
DOI：
10.1016/j.mvr.2008.07.006
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发表时间：
2008-11
影响因子：
3.1
通讯作者：
Stefanovska, A.
中科院分区：
文献类型：
--
作者：
Bernjak, A.;Clarkson, P. B. M.;McClintock, P. V. E.;Stefanovska, A.
关键词：
采用前臂皮肤激光多普勒血流仪（LDF），结合电离子透入乙酰胆碱和硝普钠和小波频谱分析，对17例新诊断为纽约心脏协会II-III级充血性心力衰竭（CHF）患者的内皮功能进行了无创性评价。用β1受体阻滞剂（比索洛尔）治疗20 ± 10周后，重复测量。还对年龄和性别匹配的健康对照组（HC）进行了测量。在每种情况下，记录数据30 min。在HC中，两种血管扩张剂之间LDF振荡的绝对频谱振幅的差异表现在频率间隔0.005-0.0095 Hz（p < 0.01）; CHF患者最初不存在这种差异，但在β1受体阻滞剂治疗后出现（p < 0.01）。对于HC，两种血管扩张剂之间的差异也表现在0.0095-0.021 Hz的标准化频谱振幅中（p < 0.05）。在CHF患者中不存在后一种差异，并且在β1受体阻滞剂治疗后无变化。它的结论是，有两个振荡的皮肤血流成分与内皮功能。两者都是CHF。β1受体阻滞剂治疗可恢复较低频率间期的活动，证实CHF与内皮功能障碍之间存在相关性，但提示涉及两种不同的机制。
Laser Doppler flowmetry (LDF) of forearm skin blood flow, combined with iontophoretically-administered acetylcholine and sodium nitroprusside and wavelet spectral analysis, was used for noninvasive evaluation of endothelial function in 17 patients newly diagnosed with New York Heart Association class II–III congestive heart failure (CHF). After 20 ± 10 weeks' treatment with a β1-blocker (Bisoprolol), the measurements were repeated. Measurements were also made on an age- and sex-matched group of healthy controls (HC). In each case data were recorded for 30 min. In HC, the difference in absolute spectral amplitude of LDF oscillations between the two vasodilators manifests in the frequency interval 0.005–0.0095 Hz (p < 0.01); this difference is initially absent in patients with CHF, but appears following the β1-blocker treatment (p < 0.01). For HC, the difference between the two vasodilators also manifests in normalised spectral amplitude in 0.0095–0.021 Hz (p < 0.05). This latter difference is absent in CHF patients and is unchanged by treatment with β1-blockers. It is concluded that there are two oscillatory skin blood flow components associated with endothelial function. Both are reduced in CHF. Activity in the lower frequency interval is restored by β1-blocker treatment, confirming the association between CHF and endothelial dysfunction but suggesting the involvement of two distinct mechanisms.
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影响因子：
8.3
作者：
BERCZI, V;STEKIEL, WJ;RUSCH, NJ
通讯作者：
RUSCH, NJ
影响因子：
5
作者：
Comini, L;Bachetti, T;Ferrari, R
通讯作者：
Ferrari, R
影响因子：
2.8
作者：
Drexler, H
通讯作者：
Drexler, H
影响因子：
3.9
作者：
Bernstein, RD;Zhang, XP;Hintze, TH
通讯作者：
Hintze, TH
影响因子：
4.6
作者：
Bandrivskyy, A;Bernjak, A;Stefanovska, A
通讯作者：
Stefanovska, A