Repeatability and Reproducibility of the Ultrasonic Attenuation Coefficient and Backscatter Coefficient Measured in the Right Lobe of the Liver in Adults With Known or Suspected Nonalcoholic Fatty Liver Disease.
Repeatability and Reproducibility of the Ultrasonic Attenuation Coefficient and Backscatter Coefficient Measured in the Right Lobe of the Liver in Adults With Known or Suspected Nonalcoholic Fatty Liver Disease.
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DOI：
10.1002/jum.14537
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发表时间：
2018-08
期刊：
影响因子：
--
通讯作者：
O'Brien WD Jr
中科院分区：
文献类型：
--
作者：
Han A;Andre MP;Deiranieh L;Housman E;Erdman JW Jr;Loomba R;Sirlin CB;O'Brien WD Jr
评估已知或疑似非酒精性脂肪性肝病（NAFLD）成人肝脏超声衰减系数（AC）和背向散射系数（BSC）测量的重复性和再现性（R&R）。机构审查委员会批准了这项符合HIPAA的前瞻性研究;获得了知情同意书。招募了41名已知或疑似NAFLD的研究参与者，并由临床超声医师使用临床扫描仪进行右肝叶的同一天超声检查。每个参与者进行两次扫描试验，参与者在试验之间重新定位。每次试验使用两个探头。对于每个换能器，超声医师优化了机器设置，但随后保持恒定，同时从肝脏获得三次数据采集，无需参与者重新定位，然后从外部校准体模获得。记录原始射频回波数据。在每次采集的用户定义的感兴趣肝野的2.6-3.0 MHz范围内测量AC和BSC。使用随机效应模型分析R&R。平均AC和对数转换BSC（logBSC）分别为0.94 dB/cm-MHz和−27.0 dB。AC的组内相关系数（ICC）为0.88-0.94，logBSC的组内相关系数（ICC）为0.87-0.95，无需受试者重新定位。对于受试者重新定位的试验间重复扫描，在对三个试验内图像的结果取平均值后，AC的ICC为0.80-0.84，logBSC的ICC为0.69-0.82。传感器引入的变异性小于重复性误差。在临床扫描仪上使用参考体模技术进行的肝脏AC和BSC测量在已知或疑似NAFLD成人的探头之间具有可重复性和可再现性。
To assess the repeatability and reproducibility (R&R) of ultrasonic attenuation coefficient (AC) and backscatter coefficient (BSC) measured in the livers of adults with known or suspected nonalcoholic fatty liver disease (NAFLD). Institutional review board approved this HIPAA-compliant prospective study; informed consent was obtained. 41 research participants with known or suspected NAFLD were recruited and underwent same-day sonograms of the right liver lobe with a clinical scanner by a clinical sonographer. Each participant underwent two scanning trials, with participant repositioning between trials. Two transducers were used in each trial. For each transducer, machine settings were optimized by the sonographer but then kept constant while three data acquisitions were obtained from the liver without participant repositioning and then from an external calibrated phantom. Raw radio-frequency echo data were recorded. AC and BSC were measured within 2.6–3.0 MHz from a user-defined hepatic field of interest from each acquisition. The R&R were analyzed using random effects models. Mean AC and log-transformed BSC (logBSC) were 0.94 dB/cm-MHz and −27.0 dB, respectively. Intraclass correlation coefficient (ICC) was 0.88–0.94 for AC and 0.87–0.95 for logBSC acquired without participant repositioning. For between-trial repeated scans with participant repositioning, the ICC was 0.80–0.84 for AC and 0.69–0.82 for logBSC after averaging results from three within-trial images. The variability introduced by the transducer was less than the repeatability error. Hepatic AC and BSC measures using a reference phantom technique on a clinical scanner are repeatable and reproducible between transducers in adults with known or suspected NAFLD.
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影响因子：
25.7
作者：
Dulai PS;Sirlin CB;Loomba R
通讯作者：
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DOI：
10.1109/tuffc.2016.2588979
发表时间：
2017-01
期刊：
IEEE transactions on ultrasonics, ferroelectrics, and frequency control
影响因子：
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作者：
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