Permissive hypercapnia and gas exchange in lungs with high Qs/Qt: a mathematical model.
Permissive hypercapnia and gas exchange in lungs with high Qs/Qt: a mathematical model.
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高 Qs/Qt 的肺部允许性高碳酸血症和气体交换：数学模型。
DOI：
--
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发表时间：
1996
影响因子：
9.8
通讯作者：
K G Hickling
中科院分区：
文献类型：
--
作者：
C J Joyce;K G Hickling
低容量通气联合允许性高碳酸血症在急性呼吸窘迫综合征的治疗中得到广泛应用。建立了一个数学模型来研究肺通气不足对肺气体交换的影响。只要吸入的氧浓度足够高，以维持PAO 2在适当的水平，肺换气不足不会恶化气体交换。在具有高分流分数的肺中，可能会导致气体交换的一些改善，但这些影响很小。高碳酸血症引起的氧-血红蛋白解离曲线右移，对急性呼吸窘迫综合征患者可能有益而无害。该分析仅限于肺通气不足和恒定分流分数的直接影响，不包括许多可能的继发性影响，如心输出量与PaCO 2的变化、与平均气道压降低相关的分流分数变化以及高碳酸血症对肺血管或气道的可能直接影响。
Low volume ventilation with permissive hypercapnia is becoming widely used in the treatment of acute respiratory distress syndrome. A mathematical model was developed to examine the effects of hypoventilation on pulmonary gas exchange in lungs with a range of shunt fractions. Hypoventilation did not worsen gas exchange, provided the inspired oxygen concentration was high enough to maintain PAO2 at an adequate level. In lungs with a high shunt fraction, some improvement in gas exchange may result, but these effects are small. A rightwards shift of the oxygen-haemoglobin dissociation curve induced by hypercapnia, is likely to be beneficial rather than detrimental in patients with acute respiratory distress syndrome. This analysis was limited to the direct effects of hypoventilation in lungs with constant shunt fractions, and did not encompass a number of possible secondary effects such as changes in cardiac output with PaCO2, changes in shunt fraction associated with a reduction in mean airway pressure and possible direct effects of hypercapnia on the pulmonary vasculature or airways.
影响因子：
3.3
作者：
BENCOWITZ, HZ;WAGNER, PD;WEST, JB
通讯作者：
WEST, JB
氧气输送到组织。
DOI：
--
发表时间：
1991
期刊：
The European respiratory journal
影响因子：
--
作者：
Samsel,RW;Schumacker,PT
通讯作者：
Schumacker,PT
心输出量增加增加分流：肺水肿和灌注作用。
DOI：
10.1152/jappl.1985.59.4.1313
发表时间：
1985
期刊：
Journal of applied physiology (Bethesda, Md. : 1985)
影响因子：
--
作者：
Breen,PH;Schumacker,PT;Sandoval,J;Mayers,I;Oppenheimer,L;Wood,LD
通讯作者：
Wood,LD