The Role of CCL2/CCR2 Axis in Cerebral Ischemia-Reperfusion Injury and Treatment: From Animal Experiments to Clinical Trials.
The Role of CCL2/CCR2 Axis in Cerebral Ischemia-Reperfusion Injury and Treatment: From Animal Experiments to Clinical Trials.
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CCL2/CCR2轴在脑缺血再灌注损伤和治疗中的作用：从动物实验到临床试验
DOI：
10.3390/ijms23073485
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发表时间：
2022-03-23
影响因子：
5.6
通讯作者：
Wang L
中科院分区：
文献类型：
--
作者：
Geng H;Chen L;Tang J;Chen Y;Wang L
C-C基序趋化因子配体2（CCL 2）是单核细胞趋化因子蛋白家族的成员，其与其受体CCR 2结合以诱导单核细胞浸润并介导炎症。CCL 2/CCR 2信号通路参与中枢神经系统中所有类型细胞之间神经炎症信息的转导。动物研究和临床试验表明，CCL 2/CCR 2介导缺血性卒中的病理过程，血清中较高的CCL 2水平与任何形式卒中的较高风险相关。在脑缺血再灌注急性期，缺血半暗带区CCL 2/CCR 2表达增加，促进神经炎症反应，加重脑损伤。后期参与神经母细胞向缺血区迁移，促进神经功能恢复。CCL 2/CCR 2基因敲除或活性抑制可减轻脑缺血再灌注引起的神经炎症和脑损伤，提示开发调控CCL 2/CCR 2信号通路活性的药物可用于防治缺血性脑卒中患者急性期细胞损伤，促进慢性期神经功能恢复。
C-C motif chemokine ligand 2 (CCL2) is a member of the monocyte chemokine protein family, which binds to its receptor CCR2 to induce monocyte infiltration and mediate inflammation. The CCL2/CCR2 signaling pathway participates in the transduction of neuroinflammatory information between all types of cells in the central nervous system. Animal studies and clinical trials have shown that CCL2/CCR2 mediate the pathological process of ischemic stroke, and a higher CCL2 level in serum is associated with a higher risk of any form of stroke. In the acute phase of cerebral ischemia-reperfusion, the expression of CCL2/CCR2 is increased in the ischemic penumbra, which promotes neuroinflammation and enhances brain injury. In the later phase, it participates in the migration of neuroblasts to the ischemic area and promotes the recovery of neurological function. CCL2/CCR2 gene knockout or activity inhibition can reduce the nerve inflammation and brain injury induced by cerebral ischemia-reperfusion, suggesting that the development of drugs regulating the activity of the CCL2/CCR2 signaling pathway could be used to prevent and treat the cell injury in the acute phase and promote the recovery of neurological function in the chronic phase in ischemic stroke patients.
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