Alpha-synuclein immunopositive aggregates in the myenteric plexus of the aging Fischer 344 rat.
Alpha-synuclein immunopositive aggregates in the myenteric plexus of the aging Fischer 344 rat.
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DOI：
10.1016/j.expneurol.2009.07.025
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发表时间：
2009-11
影响因子：
5.3
通讯作者：
Powley, Terry L.
中科院分区：
文献类型：
--
作者：
Phillips, Robert J.;Walter, Gary C.;Ringer, Brittany E.;Higgs, Katherine M.;Powley, Terry L.
关键词：
Dystrophic axons and terminals are common in the myenteric plexus and smooth muscle of the gastrointestinal (GI) tract of aged rats. In young adult rats, alpha-synuclein in its normal state is abundant throughout the myenteric plexus, making this protein--which is prone to fibrillization--a candidate marker for axonopathies in the aged rat. To determine if aggregation of alpha-synuclein is involved in the formation of age-related enteric neuropathies, we sampled the stomach, small intestine and large intestine of adult, middle-aged, and aged virgin male Fischer 344 rats stained for alpha-synuclein in both its normal and pathological states. Alpha-synuclein-positive dystrophic axons and terminals were present throughout the GI tract of middle-aged and aged rats, with immunohistochemical double-labeling demonstrating co-localization within nitric oxide synthase-, calretinin-, calbindin-, or tyrosine hydroxylase-positive markedly swollen neurites. However, other dystrophic neurites positive for each of these four markers were not co-reactive for alpha-synuclein. Similarly, a subpopulation of alpha-synuclein inclusions contained deposits immunostained with an anti-tau phospho-specific Ser262 antibody, but not all of these hyperphosphorylated tau-positive aggregates were co-localized with alpha-synuclein. The presence of heteroplastic and potentially degenerating neural elements and protein aggregates both positive and negative for alpha-synuclein suggests a complex chronological relationship between the onset of degenerative changes and the accumulation of misfolded proteins. Additionally, proteins other than alpha-synuclein appear to be involved in age-related axonopathies. Finally, this study establishes the utility of the aging Fischer 344 rat for the study of synucleopathies and tauopathies in the GI tract.
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影响因子：
5.3
作者：
BAKER, DM;SANTER, RM
通讯作者：
SANTER, RM
DOI：
10.1093/jnen/61.5.413
发表时间：
2002-05-01
影响因子：
3.2
作者：
Del Tredici, K;Rüb, U;Braak, H
通讯作者：
Braak, H
影响因子：
24.5
作者：
Cowen, T;Johnson, RJR;Santer, RM
通讯作者：
Santer, RM
影响因子：
3.3
作者：
Agnati, L. F.;Baldelli, E.;Fuxe, K.
通讯作者：
Fuxe, K.
影响因子：
3.3
作者：
Crane, Sarah J.;Talley, Nicholas J.
通讯作者：
Talley, Nicholas J.