Diffuse glioma growth: a guerilla war.
Diffuse glioma growth: a guerilla war.
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DOI：
10.1007/s00401-007-0293-7
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发表时间：
2007-11
影响因子：
12.7
通讯作者：
Wesseling P
中科院分区：
文献类型：
--
作者：
Claes A;Idema AJ;Wesseling P
与几乎所有其他脑肿瘤不同，弥漫性胶质瘤在神经细胞中广泛浸润。这种生长模式是治疗失败的主要因素。弥漫性浸润性胶质瘤细胞与游击战士有一些相似之处。在组织病理学上，肿瘤细胞倾向于单个或小群体地侵入神经元和胶质细胞突的密集网络之间。与此同时，在大面积的弥漫性胶质瘤中，肿瘤细胞滥用预先存在的氧气和营养“供应线”，而不是建立自己的“供应线”。弥漫性胶质瘤侵袭前的影像学显示是困难的。虽然关于肿瘤细胞迁移的知识正在迅速增加，但神经胶质瘤细胞浸润的确切分子机制尚未阐明。由于传统方法对抗弥漫性浸润性胶质瘤细胞的效果有限，因此可能需要一种更有针对性的（“搜索和破坏”）策略来治疗这些肿瘤。希望对原始人类胶质瘤组织以及基因型和表型相关胶质瘤模型的研究将很快提供弥漫性浸润性胶质瘤细胞的致命弱点的信息，从而可以用于更有效的治疗策略。
In contrast to almost all other brain tumors, diffuse gliomas infiltrate extensively in the neuropil. This growth pattern is a major factor in therapeutic failure. Diffuse infiltrative glioma cells show some similarities with guerilla warriors. Histopathologically, the tumor cells tend to invade individually or in small groups in between the dense network of neuronal and glial cell processes. Meanwhile, in large areas of diffuse gliomas the tumor cells abuse pre-existent “supply lines” for oxygen and nutrients rather than constructing their own. Radiological visualization of the invasive front of diffuse gliomas is difficult. Although the knowledge about migration of (tumor)cells is rapidly increasing, the exact molecular mechanisms underlying infiltration of glioma cells in the neuropil have not yet been elucidated. As the efficacy of conventional methods to fight diffuse infiltrative glioma cells is limited, a more targeted (“search & destroy”) tactic may be needed for these tumors. Hopefully, the study of original human glioma tissue and of genotypically and phenotypically relevant glioma models will soon provide information about the Achilles heel of diffuse infiltrative glioma cells that can be used for more effective therapeutic strategies.
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影响因子：
12.7
作者：
Bettinger, I;Thanos, S;Paulus, W
通讯作者：
Paulus, W
DOI：
10.1073/pnas.97.23.12846
发表时间：
2000-11-07
影响因子：
11.1
作者：
Aboody, KS;Brown, A;Snyder, EY
通讯作者：
Snyder, EY
影响因子：
3.3
作者：
Brown, MC;Cary, LA;Turner, CE
通讯作者：
Turner, CE
影响因子：
4.8
作者：
Bello, L;Lucini, V;Carroll, RS
通讯作者：
Carroll, RS
影响因子：
3.9
作者：
Asano, K;Duntsch, CD;Pourmotabbed, T
通讯作者：
Pourmotabbed, T