4-1BB functions as a survival factor in dendritic cells.
4-1BB functions as a survival factor in dendritic cells.
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4-1BB充当树突状细胞中的生存因子。
DOI：
10.4049/jimmunol.0800459
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发表时间：
2009-04-01
期刊：
影响因子：
--
通讯作者：
Kwon BS
中科院分区：
文献类型：
--
作者：
Choi BK;Kim YH;Kwon PM;Lee SC;Kang SW;Kim MS;Lee MJ;Kwon BS
4-1BB (CD137) is expressed on dendritic cells (DCs) and its biological function has remained largely unresolved. By comparing 4-1BB-intact (4-1BB+/+) and 4-1BB-deficient (4-1BB-/-) DCs, we found that 4-1BB was strongly induced on DCs during the maturation, and DC maturation was normal in the absence of 4-1BB. However, DC survival rate was low in the absence of 4-1BB, which was due to the decreased Bcl-2 and Bcl-XL in 4-1BB-/- DCs compared with 4-1BB+/+ DCs after DC maturation. Consistent with these results, 4-1BB-/- DCs showed increased turnover rate in steady state and more severely decreased in spleen by injecting LPS compared with 4-1BB+/+ DCs. When OVA-pulsed DCs were adoptively transferred to recipient mice along with OVA-specific CD4+ T cells, 4-1BB-/- DCs did not properly migrate to the T cell zone in lymph node and poorly induced proliferation of CD4+ T cells although both DCs comparably expressed functional CCR7. Eventually 4-1BB-/- DCs generated reduced number of OVA-specific memory CD4+ T cells compared to 4-1BB+/+ DCs. To further assess the role of 4-1BB on DC longevity in vivo, 4-1BB+/+ and 4-1BB-/- C57BL/6 were administrated with Propionibacterium acnes that develops liver granuloma by recruiting DCs. Number and size of granuloma were reduced in the absence of 4-1BB, but inflammatory cytokine level was comparable between the mice, which implied that the granuloma might be reduced due to the decreased longevity of DCs. These results demonstrate that 4-1BB on DCs controls the duration, DC-T interaction and therefore, immunogenicity.
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影响因子：
4.4
作者：
Park, Y;Lee, SW;Sung, YC
通讯作者：
Sung, YC
影响因子：
4.4
作者：
Kwon, BS;Hurtado, JC;Vinay, DS
通讯作者：
Vinay, DS
影响因子：
4.4
作者：
Salih, HR;Kosowski, SG;Kiener, PA
通讯作者：
Kiener, PA
影响因子：
15.3
作者：
Shuford, WW;Klussman, K;Tritchler, DD;Loo, DT;Chalupny, J;Siadak, AW;Brown, TJ;Emswiler, J;Raecho, H;Larsen, CP;Pearson, TC;Ledbetter, JA;Aruffo, A;Mittler, RS
通讯作者：
Mittler, RS
影响因子：
4.4
作者：
Katakai, T;Hara, T;Shimizu, A
通讯作者：
Shimizu, A