Pericytes Across the Lifetime in the Central Nervous System.
Pericytes Across the Lifetime in the Central Nervous System.
复制标题
DOI：
10.3389/fncel.2021.627291
复制
发表时间：
2021
影响因子：
5.3
通讯作者：
Kim Y
中科院分区：
文献类型：
--
作者：
Bennett HC;Kim Y
周细胞是一种血管周围细胞类型，包裹着大脑和脊髓的微血管。周细胞在血脑屏障（BBB）的发育和维持中起着至关重要的作用，在大脑中具有多种重要功能。最近的证据表明，周细胞损伤与各种人类疾病（如糖尿病、阿尔茨海默病（AD）和中风）相关的神经血管病理有关。虽然周细胞对正常脑功能至关重要，但对其发育轨迹和解剖分布的了解有限。本文综述了科学界目前对大脑周细胞的区域异质性及其在主要生命阶段的变化的理解。更具体地说，这篇综述文章侧重于大脑发育过程中周细胞的分化和迁移，成人大脑的区域群体差异，以及正常和病理衰老过程中的变化。我们对周细胞的了解大多来自于对大脑皮层和海马体的研究。因此，我们强调有必要扩大我们对整个大脑中周细胞分布和功能的理解，以更好地描述这种细胞类型在正常大脑和病理条件下的作用。
The pericyte is a perivascular cell type that encapsulates the microvasculature of the brain and spinal cord. Pericytes play a crucial role in the development and maintenance of the blood-brain barrier (BBB) and have a multitude of important functions in the brain. Recent evidence indicates that pericyte impairment has been implicated in neurovascular pathology associated with various human diseases such as diabetes mellitus, Alzheimer’s disease (AD), and stroke. Although the pericyte is essential for normal brain function, knowledge about its developmental trajectory and anatomical distribution is limited. This review article summarizes the scientific community’s current understanding of pericytes’ regional heterogeneity in the brain and their changes during major life stages. More specifically, this review article focuses on pericyte differentiation and migration during brain development, regional population differences in the adult brain, and changes during normal and pathological aging. Most of what is known about pericytes come from studies of the cerebral cortex and hippocampus. Therefore, we highlight the need to expand our understanding of pericyte distribution and function in the whole brain to better delineate this cell type’s role in the normal brain and pathological conditions.
登录
查看更多内容
影响因子：
4.8
作者：
Bondjers, Cecilia;He, Liqun;Betsholtz, Christer
通讯作者：
Betsholtz, Christer
影响因子：
11.8
作者：
Dave JM;Mirabella T;Weatherbee SD;Greif DM
通讯作者：
Greif DM
DOI：
10.1016/s1474-4422(16)00102-2
发表时间：
2016-06
期刊：
The Lancet. Neurology
影响因子：
--
作者：
Neurology Working Group of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium, the Stroke Genetics Network (SiGN), and the International Stroke Genetics Consortium (ISGC)
通讯作者：
Neurology Working Group of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium, the Stroke Genetics Network (SiGN), and the International Stroke Genetics Consortium (ISGC)
影响因子：
4.8
作者：
Berthiaume AA;Hartmann DA;Majesky MW;Bhat NR;Shih AY
通讯作者：
Shih AY
影响因子：
9.8
作者：
Darden J;Payne LB;Zhao H;Chappell JC
通讯作者：
Chappell JC