Pericyte Structural Remodeling in Cerebrovascular Health and Homeostasis.
Pericyte Structural Remodeling in Cerebrovascular Health and Homeostasis.
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DOI：
10.3389/fnagi.2018.00210
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发表时间：
2018
影响因子：
4.8
通讯作者：
Shih AY
中科院分区：
文献类型：
--
作者：
Berthiaume AA;Hartmann DA;Majesky MW;Bhat NR;Shih AY
脑微血管周细胞的生物学是一个活跃的研究和发现领域，因为它们与内皮细胞的相互作用对脑血管功能的多个方面至关重要。越来越多的证据表明，周细胞丢失或功能障碍与阿尔茨海默病、血管性痴呆、缺血性中风和脑损伤的发病机制有关。然而，减轻或补偿这一损失的战略仍然有限。在这篇综述中，我们重点介绍了一项新的发现，即成人大脑中的周细胞在体内是结构动态的，并通过延长其深远的过程以保持与暴露的内皮区域的接触来积极补偿内皮覆盖的丧失。周细胞的结构重塑可能为促进成人脑内周细胞与内皮细胞的交流提供了机会，并应作为一种潜在的手段来对抗痴呆和脑血管疾病中的周细胞丢失。我们讨论了周细胞丢失对毛细血管功能的病理生理影响，以及可能控制周细胞重塑的生化途径。我们还为在体内观察周细胞提供指导，以便在脑血管疾病的小鼠模型中更广泛地研究周细胞结构重塑。
The biology of brain microvascular pericytes is an active area of research and discovery, as their interaction with the endothelium is critical for multiple aspects of cerebrovascular function. There is growing evidence that pericyte loss or dysfunction is involved in the pathogenesis of Alzheimer’s disease, vascular dementia, ischemic stroke and brain injury. However, strategies to mitigate or compensate for this loss remain limited. In this review, we highlight a novel finding that pericytes in the adult brain are structurally dynamic in vivo, and actively compensate for loss of endothelial coverage by extending their far-reaching processes to maintain contact with regions of exposed endothelium. Structural remodeling of pericytes may present an opportunity to foster pericyte-endothelial communication in the adult brain and should be explored as a potential means to counteract pericyte loss in dementia and cerebrovascular disease. We discuss the pathophysiological consequences of pericyte loss on capillary function, and the biochemical pathways that may control pericyte remodeling. We also offer guidance for observing pericytes in vivo, such that pericyte structural remodeling can be more broadly studied in mouse models of cerebrovascular disease.
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DOI：
10.1073/pnas.1707702115
发表时间：
2018-06-19
影响因子：
11.1
作者：
Cai, Changsi;Fordsmann, Jonas C.;Lauritzen, Martin J.
通讯作者：
Lauritzen, Martin J.
影响因子：
64.8
作者：
Ben-Zvi, Ayal;Lacoste, Baptiste;Kur, Esther;Andreone, Benjamin J.;Mayshar, Yoav;Yan, Han;Gu, Chenghua
通讯作者：
Gu, Chenghua
影响因子：
25
作者：
Damisah EC;Hill RA;Tong L;Murray KN;Grutzendler J
通讯作者：
Grutzendler J
体内周细胞的动态重塑可在成年小鼠脑中保持毛细管覆盖率。
影响因子：
8.8
作者：
Berthiaume AA;Grant RI;McDowell KP;Underly RG;Hartmann DA;Levy M;Bhat NR;Shih AY
通讯作者：
Shih AY
影响因子：
8.8
作者：
Arango-Lievano, Margarita;Boussadia, Badreddine;Jeanneteau, Freddy
通讯作者：
Jeanneteau, Freddy