Design of a mechanical-tunable filter spectrometer for noninvasive glucose measurement.
Design of a mechanical-tunable filter spectrometer for noninvasive glucose measurement.
复制标题
用于无创血糖测量的机械可调滤光光谱仪的设计。
DOI：
10.1364/ao.43.002680
复制
发表时间：
2004
期刊：
影响因子：
1.9
通讯作者：
K. Youcef
中科院分区：
文献类型：
--
作者：
V. Saptari;K. Youcef
准确可靠的非侵入性近红外（NIR）葡萄糖传感器的开发取决于成功解决与弱葡萄糖信号和重叠NIR光谱相关的灵敏度和特异性问题。讨论了与无创血糖测量最相关的光谱硬件参数，包括光通量、积分时间、光谱范围和光谱分辨率。我们提出了一个独特的光谱系统，使用连续旋转的干涉滤波器，产生的信噪比的顺序为10（5），估计是成功的体内葡萄糖传感所需的最低。使用经典的最小二乘算法和2180和2312 nm之间的光谱范围，我们提取临床相关的葡萄糖浓度的多组分溶液中含有牛血清白蛋白，三醋精，乳酸盐和尿素。
The development of an accurate and reliable noninvasive near-infrared (NIR) glucose sensor hinges on the success in addressing the sensitivity and the specificity problems associated with the weak glucose signals and the overlapping NIR spectra. Spectroscopic hardware parameters most relevant to noninvasive blood glucose measurement are discussed, which include the optical throughput, integration time, spectral range, and the spectral resolution. We propose a unique spectroscopic system using a continuously rotating interference filter, which produces a signal-to-noise ratio of the order of 10(5) and is estimated to be the minimum required for successful in vivo glucose sensing. Using a classical least-squares algorithm and a spectral range between 2180 and 2312 nm, we extracted clinically relevant glucose concentrations in multicomponent solutions containing bovine serum albumin, triacetin, lactate, and urea.
影响因子：
7.4
作者：
ARNOLD, MA;SMALL, GW
通讯作者：
SMALL, GW
影响因子：
7.4
作者：
Pan, ST;Chung, H;Small, GW
通讯作者：
Small, GW