The Associations between Apolipoprotein E Gene Epsilon2/Epsilon3/Epsilon4 Polymorphisms and the Risk of Coronary Artery Disease in Patients with Type 2 Diabetes Mellitus.
The Associations between Apolipoprotein E Gene Epsilon2/Epsilon3/Epsilon4 Polymorphisms and the Risk of Coronary Artery Disease in Patients with Type 2 Diabetes Mellitus.
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载脂蛋白E基因Epsilon2/Epsilon3/Epsilon4多态性与2型糖尿病患者冠心病风险的关系
DOI：
10.3389/fphys.2017.01031
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发表时间：
2017
影响因子：
4
通讯作者：
Xiang DX
中科院分区：
文献类型：
--
作者：
Luo JQ;Ren H;Banh HL;Liu MZ;Xu P;Fang PF;Xiang DX
背景与目的：载脂蛋白E（Apolipoprotein E，APOE）在脂蛋白代谢和心血管疾病中起重要作用。有证据表明APOE基因ε2/ε3/ε4多态性可能与2型糖尿病（T2 DM）患者冠心病（CAD）的易感性有关。然而，尚未达成明确的共识。因此，本荟萃分析的目的是基于病例对照研究，提供APOE ε2/ε3/ε4多态性与T2 DM患者CAD风险之间潜在相关性的准确结论。研究方法：检索Pubmed、Embase、中国知网（CNKI）和万方数据库中2017年8月之前的所有相关研究（英文和中文）。合并比值比（OR）及其相应的95%置信区间（CI）用于评估相关性的强度。研究间异质性通过Cochran Q检验和I2指数进行评价，以采用固定或随机效应模型。结果：共有13项研究符合纳入条件。有证据表明APOE ε4突变与T2 DM患者的CAD风险显著相关（对于ε3/ε4 vs. ε3/ε3：OR = 1.69，95%CI = 1.38-2.08，P < 0.001;对于ε4/ε4 vs. ε3/ε3：OR = 2.72，95%CI = 1.61-4.60，P < 0.001;对于ε4/ε4+ε3/ε4 vs. ε3/ε3：OR = 1.83，95%CI = 1.52-2.22，P < 0.001; ε4等位基因与ε3等位基因：OR = 1.64，95%CI = 1.40-1.94，P < 0.001）。而APOE ε2基因突变的遗传模型中未发现明显的相关性（ε2/ε2与ε3/ε3：OR = 1.67，95% CI = 0.90-3.09，P = 0.104; ε2/ε3与ε3/ε3：OR = 1.18，95% CI = 0.93-1.51，P = 0.175; ε2/ε2+ε2/ε3对ε3/ε3：OR = 1.26，95%CI = 0.88-1.82，P = 0.212; ε2等位基因对ε3等位基因：OR = 1.34，95%CI = 0.98-1.84，P = 0.07）。结论：APOE基因ε4突变与T2 DM患者CAD风险增加相关，而ε2变异与该疾病无关。
Background and Objective: Apolipoprotein E (APOE) plays important roles in lipoprotein metabolism and cardiovascular disease. Evidence suggests the APOE gene epsilon2/epsilon3/epsilon4 (ε2/ε3/ε4) polymorphisms might be associated with the susceptibility of coronary artery disease (CAD) in patients with type 2 diabetes mellitus (T2DM). However, no clear consensus has yet been established. Therefore, the aim of this meta-analysis is to provide a precise conclusion on the potential association between APOE ε2/ε3/ε4 polymorphisms and the risk of CAD in patients with T2DM based on case-control studies. Methods: Pubmed, Embase, Chinese National Knowledge Infrastructure (CNKI), and Wanfang databases were searched for all relevant studies prior to August 2017 in English and Chinese language. The pooled odds ratios (ORs) and their corresponding 95% confidence intervals (CIs) were used to assess the strength of the relationships. The between-study heterogeneity was evaluated by Cochran's Q-test and the I2 index to adopt fixed- or random- effect models. Results: A total of 13 studies were eligible for inclusion. There was evidence for significant associations between APOE ε4 mutation and the risk of CAD in patients with T2DM (for ε3/ε4 vs. ε3/ε3: OR = 1.69, 95% CI = 1.38–2.08, P < 0.001; for ε4/ε4 vs. ε3/ε3: OR = 2.72, 95% CI = 1.61–4.60, P < 0.001; for ε4/ε4+ε3/ε4 vs. ε3/ε3: OR = 1.83, 95% CI = 1.52–2.22, P < 0.001; for ε4 allele vs. ε3 allele: OR = 1.64, 95% CI = 1.40–1.94, P < 0.001). In contrast, no significant associations were found in genetic model of APOE ε2 mutation (for ε2/ε2 vs. ε3/ε3: OR = 1.67, 95% CI = 0.90–3.09, P = 0.104; for ε2/ε3 vs. ε3/ε3: OR = 1.18, 95% CI = 0.93–1.51, P = 0.175; for ε2/ε2+ε2/ε3 vs. ε3/ε3: OR = 1.26, 95% CI = 0.88–1.82, P = 0.212; for ε2 allele vs. ε3 allele: OR = 1.34, 95% CI = 0.98–1.84, P = 0.07). Conclusions: The APOE gene ε4 mutation is associated with an increased risk of CAD in patients with T2DM, while the ε2 variation has null association with this disease.
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影响因子：
39.3
作者：
Paneni F;Beckman JA;Creager MA;Cosentino F
通讯作者：
Cosentino F
影响因子：
3.7
作者：
Larifla L;Armand C;Bangou J;Blanchet-Deverly A;Numeric P;Fonteau C;Michel CT;Ferdinand S;Bourrhis V;Vélayoudom-Céphise FL
通讯作者：
Vélayoudom-Céphise FL
影响因子：
9.3
作者：
Chaudhary R;Likidlilid A;Peerapatdit T;Tresukosol D;Srisuma S;Ratanamaneechat S;Sriratanasathavorn C
通讯作者：
Sriratanasathavorn C
影响因子：
1.9
作者：
Duval, S;Tweedie, R
通讯作者：
Tweedie, R
影响因子：
105.7
作者：
Higgins, JPT;Thompson, SG;Altman, DG
通讯作者：
Altman, DG