Association of APOE gene polymorphism with lipid profile and coronary artery disease in Afro-Caribbeans.
Association of APOE gene polymorphism with lipid profile and coronary artery disease in Afro-Caribbeans.
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DOI：
10.1371/journal.pone.0181620
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发表时间：
2017
期刊：
影响因子：
3.7
通讯作者：
Vélayoudom-Céphise FL
中科院分区：
文献类型：
--
作者：
Larifla L;Armand C;Bangou J;Blanchet-Deverly A;Numeric P;Fonteau C;Michel CT;Ferdinand S;Bourrhis V;Vélayoudom-Céphise FL
载脂蛋白E基因(APOE)基因多态性与血脂谱及心血管疾病相关。然而，这些关系在不同的民族之间有所不同。我们首次在非洲裔加勒比人群中评估了载脂蛋白E基因多态性的分布及其与冠状动脉疾病(CAD)、血脂谱和其他心脏代谢危险因素的关系。我们研究了712名非洲加勒比人受试者，其中包括220名有病历的冠心病患者和492名健康受试者。对决定载脂蛋白E等位基因ε-2、ε-3和ε-4的两个变异体rs7412和rs429358进行TaqMan分析。比较ε-2携带者、ε-3纯合子和ε-4携带者，分析载脂蛋白E基因与血脂的关系。ε-2、ε-3和ε-4在总样本中的频率分别为8%、70%和22%。冠心病与载脂蛋白E基因多态性无关。ε-4携带者总胆固醇水平高于ε-2携带者：5.07vs4.59mmo1/L(P=0.016)。载脂蛋白Eε2携带者的低密度脂蛋白胆固醇水平低于ε3纯合子和ε4携带者：分别为2.65vs3.03和3.17mmoL/L(p=0.002)。总胆固醇/高密度脂蛋白-胆固醇和低密度脂蛋白-胆固醇/高密度脂蛋白-胆固醇的比值在三个等位基因组中相似。载脂蛋白E基因多态性与糖尿病、高血压、腰围或体重指数无关。我们的结果表明，在非洲裔加勒比人中，载脂蛋白E基因多态性与血脂水平有关，但与冠心病无关。在ε4携带者中观察到的低致动脉粥样硬化特征可能解释了这种缺乏与冠心病的联系，这可能值得进一步研究。
Apolipoprotein E gene (APOE) polymorphism is associated with the lipid profile and cardio-vascular disease. However, these relationships vary between ethnic groups. We evaluated, for the first time in an Afro-Caribbean population, the distribution of APOE polymorphisms and their associations with coronary artery disease (CAD), the lipid profile and other cardio-metabolic risk factors. We studied 712 Afro-Caribbean subjects including 220 with documented CAD and 492 healthy subjects. TaqMan assays were performed to genotype rs7412 and rs429358, the two variants that determine the APOE alleles ε2, ε3 and ε4. The association between APOE genotype and the lipid profile was analysed by comparing ε2 carriers, ε3 homozygotes and ε4 carriers. The frequencies of ε2, ε3 and ε4 in the overall sample were 8%, 70% and 22%, respectively. CAD was not associated with APOE polymorphism. The total cholesterol level was higher in ε4 carriers compared with ε2 carriers: 5.07 vs 4.59 mmol/L (P = 0.016). The LDL-cholesterol level was lower in APOE ε2 carriers compared with ε3 homozygotes and ε4 carriers: 2.65 vs 3.03 and 3.17 mmol/L, respectively (p = 0.002). The total cholesterol/HDL-cholesterol and LDL-cholesterol/HDL-cholesterol ratios were similar in the three allelic groups. APOE polymorphism was not associated with diabetes, hypertension, waist circumference or body mass index. Our results indicate that APOE gene polymorphism is associated with the lipid profile but not with CAD in Afro-Caribbean people. This lack of association with CAD may be explained by the low atherogenic profile observed in ε4 carriers, which may warrant further investigation.
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