Association Between Leptin, Cognition, and Structural Brain Measures Among "Early" Middle-Aged Adults: Results from the Framingham Heart Study Third Generation Cohort.
Association Between Leptin, Cognition, and Structural Brain Measures Among "Early" Middle-Aged Adults: Results from the Framingham Heart Study Third Generation Cohort.
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DOI：
10.3233/jad-191247
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Gunstad J
中科院分区：
文献类型：
--
作者：
Sanborn V;Preis SR;Ang A;Devine S;Mez J;DeCarli C;Au R;Alosco ML;Gunstad J
临床前阿尔茨海默病（AD）的病理生理过程，包括瘦素的潜在作用，有越来越多的兴趣。人体研究表明，低水平和高水平的瘦素都可能与更差的神经认知结果有关，这表明这种关系可能受到另一个风险因素的影响。我们研究了血浆瘦素水平与神经心理学测试表现和结构神经影像学之间的关系，并评估了体重指数（BMI）是否是这些关系的影响因素。我们的研究样本包括2223名来自心脏研究第三代队列的成年人（平均年龄= 40岁，53%为女性）。在整个样本中，在调整BMI，APOE 4和其他临床因素后，瘦素与任何神经心理学领域的测量或任何MRI脑容量测量之间没有关联。然而，我们确实观察到BMI类别是瘦素和言语记忆之间关联的效应修饰符（交互作用的p值=0.03），其中在正常体重参与者（BMI 18.5-24.9）kg/m2中，更高水平的瘦素与更好的表现相关（β =0.12，p值=0.02）。在超重或肥胖的参与者中，没有观察到瘦素水平和非文字记忆测试表现之间的关联。这些发现表明瘦素和认知功能之间的关联是由BMI类别调节的。对从中年过渡到老年的个体进行前瞻性检查将有助于阐明瘦素对AD和其他神经退行性疾病的贡献。
There is growing interest in the pathophysiological processes of preclinical Alzheimer’s disease (AD), including the potential role of leptin. Human studies have shown that both low and high levels of leptin can be associated with worse neurocognitive outcomes, suggesting this relationship may be moderated by another risk factor. We examined the association between plasma leptin levels and both neuropsychological test performance and structural neuroimaging and assessed whether body mass index (BMI) is an effect modifier of these associations. Our study sample consisted of 2223 adults from the Framingham Heart Study Third Generation Cohort (average age = 40 years, 53% women). Among the entire sample, there was no association between leptin and any of the neuropsychological domain measures or any of the MRI brain volume measures, after adjustment for BMI, APOE4, and other clinical factors. However, we did observe that BMI category was an effect modifier for the association between leptin and verbal memory (p-value for interaction=0.03), where higher levels of leptin were associated with better performance among normal weight participants (BMI 18.5–24.9) kg/m2 (beta=0.12, p-value=0.02). No association was observed between leptin level and verbal memory test performance among participants who were overweight or obese. These findings suggest that the association between leptin and cognitive function is moderated by BMI category. Prospective examination of individuals transitioning from middle age to older adulthood will help to clarify the contribution of leptin to AD and other neurodegenerative conditions.
影响因子：
3.9
作者：
Lee J;Kim J;Shin SA;Park S;Yoon DH;Kim H;Kim YK;Moon MK;Koo BK;Lee JY
通讯作者：
Lee JY