Moderating Effect of Insulin Resistance on the Relationship between Gray Matter Volumes and Cognitive Function.
Moderating Effect of Insulin Resistance on the Relationship between Gray Matter Volumes and Cognitive Function.
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DOI：
10.3390/jcm7110413
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发表时间：
2018-11-04
影响因子：
3.9
通讯作者：
Lee JY
中科院分区：
文献类型：
--
作者：
Lee J;Kim J;Shin SA;Park S;Yoon DH;Kim H;Kim YK;Moon MK;Koo BK;Lee JY
背景：暴露于胰岛素抵抗是否会加速认知恶化存在争议。本研究旨在调查胰岛素抵抗与灰质体积减少之间的关联，以预测认知能力下降。方法：我们招募了 160 名参与者（78 名患有阿尔茨海默病，82 名没有阿尔茨海默病）。评估胰岛素抵抗、局部灰质体积和认知功能。使用分层调节多元回归（MMR）模型来确定胰岛素抵抗、大脑结构变化和认知能力下降之间的关联。结果：灰质中 7 个区域的体积与阿尔茨海默病的胰岛素抵抗呈负相关（p = 0.032）。分层 MMR 分析表明，胰岛素抵抗并不直接影响认知能力下降，而是通过关键脑区灰质体积的减少来缓解认知能力下降，即眶额下回（左）、中扣带回（右）、海马（右）和楔前叶（右）（每种情况下 p < 0.05）。结论：胰岛素抵抗似乎会加剧与灰质体积减少相关的认知能力下降。
Background: It is controversial whether exposure to insulin resistance accelerates cognitive deterioration. The present study aimed to investigate the association between insulin resistance and gray matter volume loss to predict the cognitive decline. Methods: We recruited 160 participants (78 with Alzheimer’s disease and 82 without Alzheimer’s disease). Insulin resistance, regional gray matter volume, and cognitive function were assessed. A hierarchical moderated multiple regression (MMR) model was used to determine any associations among insulin resistance, structural changes in the brain, and cognitive decline. Results: The volumes of 7 regions in the gray matter were negatively related to insulin resistance in Alzheimer’s disease (p =0.032). Hierarchical MMR analysis indicated that insulin resistance did not directly affect the cognitive decline but moderated the cognitive decline through the decrease in gray matter volume in the key brain regions, i.e., inferior orbitofrontal gyrus (left), middle cingulate gyrus (right), hippocampus (right), and precuneus (right) (p < 0.05 in each case). Conclusion: Insulin resistance appears to exacerbate the cognitive decline associated with several gray matter volume loss.
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DOI：
10.1038/nrneurol.2017.185
发表时间：
2018-03
期刊：
Nature reviews. Neurology
影响因子：
--
作者：
Arnold SE;Arvanitakis Z;Macauley-Rambach SL;Koenig AM;Wang HY;Ahima RS;Craft S;Gandy S;Buettner C;Stoeckel LE;Holtzman DM;Nathan DM
通讯作者：
Nathan DM
影响因子：
4.2
作者：
Morris JK;Vidoni ED;Honea RA;Burns JM;Alzheimer's Disease Neuroimaging Initiative
通讯作者：
Alzheimer's Disease Neuroimaging Initiative
胰岛素与阿尔茨海默氏病和衰老的认知下降和萎缩有不同的关系。
DOI：
10.1016/j.bbadis.2011.06.011
发表时间：
2012-03
影响因子：
6.2
作者：
Burns, Jeffrey M.;Honea, Robyn A.;Vidoni, Eric D.;Hutfles, Lewis J.;Brooks, William M.;Swerdlow, Russell H.
通讯作者：
Swerdlow, Russell H.
影响因子：
3.8
作者：
de la Monte SM
通讯作者：
de la Monte SM
影响因子：
7.7
作者：
Neergaard, Jesper S.;Dragsbaek, Katrine;Henriksen, Kim
通讯作者：
Henriksen, Kim