Dietary agents in cancer prevention: an immunological perspective.

Dietary agents in cancer prevention: an immunological perspective.
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DOI:
10.1111/j.1751-1097.2012.01128.x
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发表时间:
2012-09
影响因子:
3.3
通讯作者:
Mehrotra S
Mehrotra S
中科院分区:
生物学3区
文献类型:
--
作者:
Zheng YY;Viswanathan B;Kesarwani P;Mehrotra S

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皮肤癌是美国诊断出的最常见的癌症形式。暴露在太阳紫外线(UV)辐射下被认为是皮肤癌的主要原因。过度的紫外线辐射会导致皮肤细胞DNA的基因突变和损伤,进而导致皮肤癌。最近,通过使用自然产生的无毒饮食化合物进行化学预防已被证明是预防肿瘤发生的一种潜在策略。人们已经注意到了几种天然的膳食剂,如葡萄、红酒、浆果和花生中的主要成分白藜芦醇,葡萄籽中的原花青素,绿茶中的(-)-表没食子儿茶素没食子酸酯(EGCG)等。然而,这些膳食剂对免疫系统的影响和涉及的免疫学机制仍在探索中。在这篇综述中,我们将集中讨论关键的化学预防药物在各种免疫细胞中的作用,并从免疫学的角度讨论它们作为抗肿瘤药物的潜力。
Skin cancer is the most common form of cancer diagnosed in the United States. Exposure to solar ultraviolet (UV) radiations is believed to be the primary cause for skin cancer. Excessive UV radiation can lead to genetic mutations and damage in the skin's cellular DNA that in turn can lead to skin cancer. Lately, chemoprevention by administering naturally occurring non-toxic dietary compounds has proven to be a potential strategy to prevent the occurrence of tumors. Attention has been drawn towards several natural dietary agents such as resveratrol, one of the major components found in grapes, red wines, berries and peanuts, proanthocyanidins from grape seeds, (-)-epigallocatechin-3-gallate (EGCG) from green tea etc. However, the effect these dietary agents have on the immune system and the immunological mechanisms involved there in are still being explored. In this review we shall focus on the role of key chemopreventive agents on various immune cells and discuss their potential as anti-tumor agents with an immunological perspective.
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