Anti-inflammatory effects of resveratrol, curcumin and simvastatin in acute small intestinal inflammation.
Anti-inflammatory effects of resveratrol, curcumin and simvastatin in acute small intestinal inflammation.
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DOI：
10.1371/journal.pone.0015099
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发表时间：
2010-12-03
期刊：
影响因子：
3.7
通讯作者：
Heimesaat MM
中科院分区：
文献类型：
--
作者：
Bereswill S;Muñoz M;Fischer A;Plickert R;Haag LM;Otto B;Kühl AA;Loddenkemper C;Göbel UB;Heimesaat MM
白藜芦醇、姜黄素和辛伐他汀的健康有益作用已在各种炎症实验模型中得到证实。我们研究了上述化合物在弓形虫经口感染后超急性Th 1型回肠炎小鼠模型中的潜在抗炎和免疫调节机制。在这里，我们表明，口服白藜芦醇，姜黄素或辛伐他汀后，小鼠受到保护，从回肠炎的发展和存活的急性期炎症，而所有安慰剂治疗的对照死亡。特别是，白藜芦醇治疗导致长期生存。与安慰剂对照动物相比，白藜芦醇、姜黄素或辛伐他汀处理的动物显示出调节性T细胞数量显著增加，并且回肠粘膜中肠上皮细胞增殖/再生增强。与此相反，治疗组小鼠粘膜T淋巴细胞和嗜中性粒细胞数量减少。此外，与安慰剂对照组相比，给药动物回肠、肠系膜淋巴结和脾脏中抗炎细胞因子IL-10的水平升高，而促炎细胞因子表达（IL-23 p19、IFN-γ、TNF-α、IL-6、MCP-1）显著降低。此外，治疗的动物不仅表现出更少的促炎性肠杆菌和肠球菌，而且还表现出更高的抗炎性乳酸杆菌和双歧杆菌载量。最重要的是，用所有三种化合物治疗保留了肠屏障功能，如通过降低细菌移位到脾、肝、肾和血液中的速率所指示的。口服白藜芦醇、姜黄素或辛伐他汀可通过下调Th 1型免疫应答来改善急性小肠炎症，并通过维持肠道屏障功能来防止细菌移位。这些发现为炎症性肠病患者提供了新的和潜在的预防和治疗选择。
The health beneficial effects of Resveratrol, Curcumin and Simvastatin have been demonstrated in various experimental models of inflammation. We investigated the potential anti-inflammatory and immunomodulatory mechanisms of the above mentioned compounds in a murine model of hyper-acute Th1-type ileitis following peroral infection with Toxoplasma gondii. Here we show that after peroral administration of Resveratrol, Curcumin or Simvastatin, mice were protected from ileitis development and survived the acute phase of inflammation whereas all Placebo treated controls died. In particular, Resveratrol treatment resulted in longer-term survival. Resveratrol, Curcumin or Simvastatin treated animals displayed significantly increased numbers of regulatory T cells and augmented intestinal epithelial cell proliferation/regeneration in the ileum mucosa compared to placebo control animals. In contrast, mucosal T lymphocyte and neutrophilic granulocyte numbers in treated mice were reduced. In addition, levels of the anti-inflammatory cytokine IL-10 in ileum, mesenteric lymph nodes and spleen were increased whereas pro-inflammatory cytokine expression (IL-23p19, IFN-γ, TNF-α, IL-6, MCP-1) was found to be significantly lower in the ileum of treated animals as compared to Placebo controls. Furthermore, treated animals displayed not only fewer pro-inflammatory enterobacteria and enterococci but also higher anti-inflammatory lactobacilli and bifidobacteria loads. Most importantly, treatment with all three compounds preserved intestinal barrier functions as indicated by reduced bacterial translocation rates into spleen, liver, kidney and blood. Oral treatment with Resveratrol, Curcumin or Simvastatin ameliorates acute small intestinal inflammation by down-regulating Th1-type immune responses and prevents bacterial translocation by maintaining gut barrier function. These findings provide novel and potential prophylaxis and treatment options of patients with inflammatory bowel diseases.
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影响因子：
6.4
作者：
Liesenfeld, O
通讯作者：
Liesenfeld, O
DOI：
10.1073/pnas.88.12.5292
发表时间：
1991-06-01
影响因子：
11.1
作者：
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通讯作者：
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影响因子：
64.8
作者：
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通讯作者：
Sinclair, David A.
影响因子：
5
作者：
Kouri, TT;Gant, VA;Guder, WG
通讯作者：
Guder, WG
影响因子：
2.1
作者：
Basset, Christelle;Holton, John
通讯作者：
Holton, John