Intrarenal neurohormonal modulation by renal denervation: benefits for chronic kidney disease and heart failure
Intrarenal neurohormonal modulation by renal denervation: benefits for chronic kidney disease and heart failure
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通过肾去神经支配进行肾内神经激素调节：对慢性肾病和心力衰竭的益处
DOI：
10.1038/s41440-022-01104-x
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发表时间：
2022
影响因子：
5.4
通讯作者：
Kario Kazuomi
中科院分区：
文献类型：
--
作者：
Katsurada Kenichi;Kario Kazuomi
交感神经系统的过度激活是高血压的病理生理标志之一。肾去神经支配（RDN）是一种改变循环调节系统的神经调节疗法，因其降低心血管疾病发病率和严重程度的潜力而受到关注。肾脏是循环液体量的主要调节者，其功能障碍与高血压的发病直接相关。这种治疗包括部分阻断肾交感神经系统，这是大脑和肾脏之间的器官连接途径。最近发表的随机对照试验（即SPYRAL HTN-OFF MED/ON MED试验和radian - htn SOLO/TRIO试验）表明，基于导管的RDN具有明显的降压作用[1-4]，除高血压外，还有望扩大慢性肾脏疾病和心力衰竭的治疗靶点。然而，在将RDN引入临床之前，必须建立一个准确有效的程序。此外，RDN抗高血压作用的具体机制尚未完全阐明。Lai等人发表在本期《高血压研究》杂志上的一项研究中，研究了选择性RDN对肾内肾素-血管紧张素系统（RAS）和参与钠和水重吸收的转运蛋白的影响。该研究是该实验室先前工作的延伸，其重点是RDN方法用于确定最佳消融靶点[6]。有选择性的RDN。
Excessive activation of the sympathetic nervous system is one of the pathophysiological hallmarks of hypertension. Renal denervation (RDN), a neuromodulation therapy that modifies the circulatory regulatory system, has attracted attention for its potential to reduce the incidence and severity of cardiovascular diseases. The kidneys are the major regulators of circulating fluid volume, and their dysfunction is directly linked to the pathogenesis of hypertension. This treatment involves partial blockade of the renal sympathetic nervous system, which is an organ-connected pathway between the brain and the kidneys. Recently, published randomized controlled trials (ie, the SPYRAL HTN-OFF MED/ON MED trial and the RADIANCE-HTN SOLO/TRIO trial) have shown that catheter-based RDN has a clear antihypertensive effect [1–4] and is expected to expand the therapeutic targets for chronic kidney disease and heart failure in addition to hypertension. However, before RDN can be introduced into the clinic, an accurate and efficient procedure must be established. Furthermore, the detailed mechanism of the antihypertensive effect of RDN has not been fully elucidated.In a study published in this issue of Hypertension Research [5], Lai et al. examined the effect of selective RDN on the intrarenal renin-angiotensin system (RAS) and transporters involved in sodium and water reabsorption. The study was an extension of previous work from the same laboratory focusing on the method of RDN for the identification of optimal ablation targets [6]. Selective RDN,
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影响因子：
24
作者：
Sharp, Thomas E., III;Polhemus, David J.;Goodchild, Traci T.
通讯作者：
Goodchild, Traci T.
24小时血压管理基本手册：从早晨高血压到夜间高血压
影响因子：
10
作者：
K. Kario
通讯作者：
K. Kario
影响因子：
15.9
作者：
Gonzalez-Villalobos, Romer A.;Janjoulia, Tea;McDonough, Alicia A.
通讯作者：
McDonough, Alicia A.
肾去神经支配后，在不同强度的血压反应的引导下，肾内血压调节系统发生差异性改变
影响因子：
5.4
作者：
Yinchuan Lai;Hao Zhou;Weijie Chen;Hang Liu;Guangliang Liu;Yan;Huaan Du;Bo Zhang;Yidan Li;Kamsang Woo;Y. Yin
通讯作者：
Y. Yin
DOI：
10.1016/s0140-6736(21)00788-1
发表时间：
2021-06-26
期刊：
Lancet (London, England)
影响因子：
--
作者：
Azizi, Michel;Sanghvi, Kintur;Kirtane, Ajay J
通讯作者：
Kirtane, Ajay J