ZnO Nanowire-Anchored Microfluidic Device With Herringbone Structure Fabricated by Maskless Photolithography
ZnO Nanowire-Anchored Microfluidic Device With Herringbone Structure Fabricated by Maskless Photolithography
复制标题
无掩模光刻法制备人字形结构的氧化锌纳米线锚定微流控器件
DOI：
10.1177/1179597220941431
复制
发表时间：
2020
影响因子：
2.8
通讯作者：
George Z. Tan
中科院分区：
文献类型：
--
作者：
Dilshan Sooriyaarachchi;Shahrima Maharubin;George Z. Tan
纳米材料在微流控器件中的集成已成为一种新的研究范式。采用ZnO纳米线组成的微流控装置用于高效收集尿液细胞外囊泡（ev）和原位提取各种microrna （mirna）。该设备可用于诊断各种疾病，包括肾脏疾病和癌症。提高萃取效率是开发微总量分析系统的主要研究需求。本文提出了一种新型的以ZnO纳米线阵列为锚定结构的人字纹微流控器件的制备方法。采用无掩模光刻技术制备了人字形衬底。采用化学浴法在衬底上生长ZnO纳米线阵列。图案设计是为了引入湍流，而不是传统装置中的层流，以增加尿液样品与ZnO纳米线的混合和接触。与传统的平面微流体通道相比，该装置的流速降低，并成功提取了尿液ev封装的miRNAs。
The integration of nanomaterials in microfluidic devices has emerged as a new research paradigm. Microfluidic devices composed of ZnO nanowires have been developed for the collection of urine extracellular vesicles (EVs) at high efficiency and in situ extraction of various microRNAs (miRNAs). The devices can be used for diagnosing various diseases, including kidney diseases and cancers. A major research need for developing micro total analysis systems is to enhance extraction efficiency. This article presents a novel fabrication method for a herringbone-patterned microfluidic device anchored with ZnO nanowire arrays. The substrates with herringbone patterns were created by maskless photolithography. The ZnO nanowire arrays were grown on the substrates by chemical bathing. The patterned design was to introduce turbulent flows as opposed to laminar flow in traditional devices to increase the mixing and contact of the urine sample with ZnO nanowires. The device showed reduced flow rates compared with conventional planar microfluidic channels and successfully extracted urine EV-encapsulated miRNAs.
影响因子：
15
作者：
Sameenoi, Yupaporn;Koehler, Kirsten;Shapiro, Jeff;Boonsong, Kanokporn;Sun, Yele;Collett, Jeffrey, Jr.;Volckens, John;Henry, Charles S.
通讯作者：
Henry, Charles S.
影响因子：
7.4
作者：
Sun J;Gao Y;Isaacs RJ;Boelte KC;Lin PC;Boczko EM;Li D
通讯作者：
Li D