Active sampling and decision making in Drosophila chemotaxis.
Active sampling and decision making in Drosophila chemotaxis.
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DOI：
10.1038/ncomms1455
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发表时间：
2011-08-23
影响因子：
16.6
通讯作者：
中科院分区：
文献类型：
--
作者：
对化学刺激的反应能力是能动生物生存的基础，但气味跟踪的基本策略仍然知之甚少。在这里，我们表明，果蝇幼虫的趋化性是一个积极的采样过程类似于脊椎动物的嗅探。结合计算机视觉算法与重建的嗅觉环境，我们建立幼虫定向气味梯度通过一个顺序组织的刻板行为，包括运行，停止，侧头投和定向转向。负梯度，在运行过程中集成，控制转弯的时机。通过高振幅头模检测到的正梯度确定了个体转弯的方向。通过遗传操纵外周嗅觉回路，我们研究方向如何适应嗅觉输入功能的损失和增益。我们的研究结果表明，幼虫的趋化性是一个中间的导航策略之间的偏见随机游走的大肠杆菌和立体嗅觉观察大鼠和人类。果蝇幼虫表现出对气味的趋化性，但其导航机制知之甚少。Gomez-Marin等人使用计算机视觉跟踪，表明幼虫使用类似于脊椎动物嗅探的主动采样策略来提升气味梯度。
The ability to respond to chemical stimuli is fundamental to the survival of motile organisms, but the strategies underlying odour tracking remain poorly understood. Here we show that chemotaxis in Drosophila melanogaster larvae is an active sampling process analogous to sniffing in vertebrates. Combining computer-vision algorithms with reconstructed olfactory environments, we establish that larvae orient in odour gradients through a sequential organization of stereotypical behaviours, including runs, stops, lateral head casts and directed turns. Negative gradients, integrated during runs, control the timing of turns. Positive gradients detected through high-amplitude head casts determine the direction of individual turns. By genetically manipulating the peripheral olfactory circuit, we examine how orientation adapts to losses and gains of function in olfactory input. Our findings suggest that larval chemotaxis represents an intermediate navigation strategy between the biased random walks of Escherichia Coli and the stereo-olfaction observed in rats and humans. Drosophila melanogaster larvae demonstrate chemotaxis towards odours but their navigation mechanism is poorly understood. Using computer-vision tracking, Gomez-Marin et al. show that larvae ascend odour gradients using an active sampling strategy that is analogous to sniffing in vertebrates.
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影响因子：
9.2
作者：
Maimon, Gaby;Straw, Andrew D.;Dickinson, Michael H.
通讯作者：
Dickinson, Michael H.
影响因子：
25
作者：
Louis, Matthieu;Huber, Thomas;Vosshall, Leslie B.
通讯作者：
Vosshall, Leslie B.
影响因子：
5.3
作者：
Gomez-Marin A;Duistermars BJ;Frye MA;Louis M
通讯作者：
Louis M
DOI：
10.1016/j.cub.2009.06.022
发表时间：
2009-08-11
期刊：
Current biology : CB
影响因子：
--
作者：
Duistermars BJ;Chow DM;Frye MA
通讯作者：
Frye MA
影响因子：
1.6
作者：
Beglane, PF;Grasso, FW;Atema, J
通讯作者：
Atema, J