Anti-citrullinated peptide antibody-negative RA is a genetically distinct subset: a definitive study using only bone-erosive ACPA-negative rheumatoid arthritis.
Anti-citrullinated peptide antibody-negative RA is a genetically distinct subset: a definitive study using only bone-erosive ACPA-negative rheumatoid arthritis.
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DOI：
10.1093/rheumatology/keq273
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发表时间：
2010-12
期刊：
影响因子：
--
通讯作者：
Mimori T
中科院分区：
文献类型：
--
作者：
Ohmura K;Terao C;Maruya E;Katayama M;Matoba K;Shimada K;Murasawa A;Honjo S;Takasugi K;Tohma S;Matsuo K;Tajima K;Yukawa N;Kawabata D;Nojima T;Fujii T;Yamada R;Saji H;Matsuda F;Mimori T
目标. ACPA是RA的高度特异性标志物。最近有报道ACPA可用于将RA分为ACPA阳性和ACPA阴性两个疾病亚群。ACPA阳性RA与HLA-DR共享表位（SE）相关，而ACPA阴性RA与SE无关。然而，仍然怀疑这一结果是由ACPA阴性的RA亚组（包含非RA疾病患者）引起的。我们研究了是否是这种情况下，即使可能的非RA ACPA阴性的RA患者被排除在外，只选择骨侵蚀的患者。方法.我们对574例ACPA阳性RA、185例ACPA阴性RA（包括97例糜烂型RA）和1508例健康人进行了HLA-DRB 1等位基因分型。我们还测试了HLA-DR SE是否与RF阴性或ANA阴性RA相关。结果ACPA阴性RA伴明显骨质侵蚀与SE无关，支持ACPA阴性RA与ACPA阳性RA在遗传上不同的观点。我们还测试了这些子集是否基于自身抗体产生活性。与ACPA阴性RA亚组一致，RF阴性RA亚组与SE的相关模式与RF阳性RA明显不同。相反，ANA阴性和ANA阳性RA与SE相似，表明ACPA区分的亚群不仅仅基于自身抗体产生的差异。结论. ACPA阴性糜烂性RA与ACPA阳性RA在遗传上不同。
Objectives. ACPA is a highly specific marker for RA. It was recently reported that ACPA can be used to classify RA into two disease subsets, ACPA-positive and ACPA-negative RA. ACPA-positive RA was found to be associated with the HLA-DR shared epitope (SE), but ACPA negative was not. However, the suspicion remained that this result was caused by the ACPA-negative RA subset containing patients with non-RA diseases. We examined whether this is the case even when possible non-RA ACPA-negative RA patients were excluded by selecting only patients with bone erosion. Methods. We genotyped HLA-DRB1 alleles for 574 ACPA-positive RA, 185 ACPA-negative RA (including 97 erosive RA) and 1508 healthy donors. We also tested whether HLA-DR SE is associated with RF-negative or ANA-negative RA. Results. ACPA-negative RA with apparent bone erosion was not associated with SE, supporting the idea that ACPA-negative RA is genetically distinct from ACPA-positive RA. We also tested whether these subsets are based on autoantibody-producing activity. In accordance with the ACPA-negative RA subset, the RF-negative RA subset showed a clearly distinct pattern of association with SE from the RF-positive RA. In contrast, ANA-negative as well as ANA-positive RA was similarly associated with SE, suggesting that the subsets distinguished by ACPA are not based simply on differences in autoantibody production. Conclusions. ACPA-negative erosive RA is genetically distinct from ACPA-positive RA.
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影响因子：
9.8
作者：
Kallberg, Henrik;Padyukov, Leonid;Alfredsson, Lars
通讯作者：
Alfredsson, Lars
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Ronnblom, Lars
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通讯作者：
Roudier, Jean
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5.9
作者：
OLSEN, NJ;CALLAHAN, LF;PINCUS, T
通讯作者：
PINCUS, T