High-Quality Diets Associate With Reduced Risk of Colorectal Cancer: Analyses of Diet Quality Indexes in the Multiethnic Cohort.
High-Quality Diets Associate With Reduced Risk of Colorectal Cancer: Analyses of Diet Quality Indexes in the Multiethnic Cohort.
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DOI：
10.1053/j.gastro.2017.04.004
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发表时间：
2017-08
期刊：
影响因子：
29.4
通讯作者：
Le Marchand L
中科院分区：
文献类型：
--
作者：
Park SY;Boushey CJ;Wilkens LR;Haiman CA;Le Marchand L
通过饮食质量指数(DQI)评估的健康饮食模式与较低的结直肠癌风险有关--主要是在白人中。我们在多种族队列中调查了4个DQI评分(2010年健康饮食指数[HEI-2010]、2010年另类健康饮食指数[AHEI-2010]、替代地中海饮食评分[Amed]和停止高血压饮食方法评分)与结直肠癌风险的关系。我们分析了190,949名非洲裔美国人、夏威夷原住民、日裔美国人、拉丁裔和白人的数据，他们年龄在45-75岁之间，从1993年到1996年进入了多种族队列研究。在平均16年的随访中，4770例侵袭性结直肠癌病例被确定。所有4个DQI的得分与结直肠癌风险呈负相关；得分较高与降低结直肠癌风险相关(Trend≤均为P。003)。在调整协变量后，女性的AHEI-2010和AMED得分的相关性不显著：对于最高和最低的五分位数，男性HEI-2010得分的风险比为0.69(95%CI，0.59-0.80)，女性为0.82(95%CI，0.70-0.96)；AHEI-2010得分的风险比男性为0.75(95%CI，0.65-0.85)，女性为0.90(95%CI，0.78-1.04)；对于AMED评分，男性的风险比为0.84(95%CI，0.73-0.97)，女性为0.96(95%CI，0.82-1.13)；对于饮食治疗高血压评分，男性的风险比为0.75(95%CI，0.66-0.86)，女性为0.86(95%CI，0.75-1.00)。所有指标的关联性仅限于左半结肠和直肠。与其他4个种族/民族相比，非洲裔美国人的这种反向关联不那么强烈。根据对多种族队列研究数据的分析，在大多数种族/民族亚组中，高质量的饮食与较低的结直肠癌风险有关。
Healthy eating patterns assessed by diet quality indexes (DQIs) have been related to lower risk of colorectal cancer—mostly among whites. We investigated the associations between 4 DQI scores (the Healthy Eating Index 2010 [HEI-2010], the Alternative Healthy Eating Index 2010 [AHEI-2010], the alternate Mediterranean diet score [aMED], and the Dietary Approaches to Stop Hypertension score) and colorectal cancer risk in the Multiethnic Cohort. We analyzed data from 190,949 African Americans, Native Hawaiians, Japanese Americans, Latinos and whites, 45–75 years old, who entered the Multiethnic Cohort study from 1993 through 1996. During an average 16 years of follow up, 4770 invasive colorectal cancer cases were identified. Scores from all 4 DQIs associated inversely with colorectal cancer risk; higher scores associated with decreasing colorectal cancer risk (all P's for trend ≤ .003). Associations were not significant for AHEI-2010 and aMED scores in women after adjustment for covariates: for the highest vs lowest quintiles, the hazard ratio for the HEI-2010 score in men was 0.69 (95% CI, 0.59–0.80) and in women was 0.82 (95% CI , 0.70–0.96); for the AHEI-2010 score the hazard ratio in men was 0.75 (95% CI , 0.65–0.85) and in women was 0.90 (95% CI , 0.78–1.04); for the aMED score the hazard ratio in men was 0.84 (95% CI , 0.73–0.97) and in women was 0.96 (95% CI , 0.82–1.13); for the Dietary Approaches to Stop Hypertension score the hazard ratio in men was 0.75 (95% CI , 0.66–0.86) and in women was 0.86 (95% CI , 0.75–1.00). Associations were limited to the left colon and rectum for all indexes. The inverse associations were less strong in African Americans than in the other 4 racial/ethnic groups. Based on an analysis of data from the Multiethnic Cohort Study, high-quality diets are associated with a lower risk of colorectal cancer in most racial/ethnic subgroups.
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影响因子：
6.4
作者：
Ollberding, Nicholas J.;Nomura, Abraham M. Y.;Wilkens, Lynne R.;Henderson, Brian E.;Kolonel, Laurence N.
通讯作者：
Kolonel, Laurence N.
影响因子：
6.4
作者：
Ollberding, Nicholas J.;Wilkens, Lynne R.;Henderson, Brian E.;Kolonel, Laurence N.;Le Marchand, Loic
通讯作者：
Le Marchand, Loic
影响因子：
5
作者：
Park, Song-Yi;Murphy, Suzanne P.;Kolonel, Laurence N.
通讯作者：
Kolonel, Laurence N.
影响因子：
2.3
作者：
Nomura, Abraham M. Y.;Hankin, Jean H.;Kolonel, Laurence N.
通讯作者：
Kolonel, Laurence N.
影响因子：
7.1
作者：
Harmon, Brook E.;Boushey, Carol J.;Kolonel, Laurence N.
通讯作者：
Kolonel, Laurence N.