The Expression of Fibroblast Activation Protein in Clear Cell Renal Cell Carcinomas Is Associated with Synchronous Lymph Node Metastases.
The Expression of Fibroblast Activation Protein in Clear Cell Renal Cell Carcinomas Is Associated with Synchronous Lymph Node Metastases.
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DOI：
10.1371/journal.pone.0169105
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Larrinaga G
中科院分区：
文献类型：
--
作者：
Errarte P;Guarch R;Pulido R;Blanco L;Nunes-Xavier CE;Beitia M;Gil J;Angulo JC;López JI;Larrinaga G
透明细胞肾细胞癌（CCRCC）是一种异质且复杂的疾病，经常发生远处转移。成纤维细胞激活蛋白（FAP）是一种丝氨酸肽酶，其在癌症相关成纤维细胞中的表达与较高的转移风险和较差的生存率相关。本研究的目的是评估 FAP 在转移性 CCRCC (mCCRCC) 中的作用。该研究纳入了一系列回顾性收集的 59 个 mCCRCC。转移瘤与肾脏疾病同步发生（n = 14）或异时发生（n = 45）。从原发灶 (n = 59) 和转移灶 (n = 54) 中获取肿瘤标本，并对 FAP 表达进行免疫组织化学分析。原发肿瘤成纤维细胞中的 FAP 表达与相应转移灶中的 FAP 表达相关。此外，原发性和转移性FAP表达与大肿瘤直径（>7cm）、高级别（G3/4）、高分期（pT3/4）、肿瘤坏死和肉瘤样转化相关。原发肿瘤及其转移瘤中 FAP 的表达与同步转移以及淋巴结转移相关。原发肿瘤中的 FAP 表达与较差的 10 年总生存率相关。间质瘤成纤维细胞中 FAP 的免疫组织化学检测可能是早期淋巴结转移状态的生物标志物，因此可以解释 FAP 阳性 CCRCC 的不良预后。
Clear cell renal cell carcinoma (CCRCC) is a heterogeneous and complex disease that frequently develops distant metastases. Fibroblast activation protein (FAP) is a serine peptidase the expression of which in cancer-associated fibroblasts has been associated with higher risk of metastases and poor survival. The objective of this study was to evaluate the role of FAP in metastatic CCRCC (mCCRCC). A series of 59 mCCRCC retrospectively collected was included in the study. Metastases developed either synchronous (n = 14) or metachronous to renal disease (n = 45). Tumor specimens were obtained from both primary lesion (n = 59) and metastases (n = 54) and FAP expression was immunohistochemically analyzed. FAP expression in fibroblasts from primary tumors correlated with FAP expression in the corresponding metastatic lesions. Also, primary and metastatic FAP expression was correlated with large tumor diameter (>7cm), high grade (G3/4), high stage (pT3/4), tumor necrosis and sarcomatoid transformation. The expression of FAP in primary tumors and in their metastases was associated both with synchronous metastases and also with metastases to the lymph nodes. FAP expression in the primary tumor was correlated with worse 10-year overall survival. Immunohistochemical detection of FAP in the stromal tumor fibroblasts could be a biomarker of early lymph node metastatic status and therefore could account for the poor prognosis of FAP positive CCRCC.
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影响因子：
3.3
作者：
Bostrom, Anna-Karin;Moller, Christina;Johansson, Martin E.
通讯作者：
Johansson, Martin E.
DOI：
10.1002/pros.23145
发表时间：
2016-05
期刊：
The Prostate
影响因子：
--
作者：
Brennen WN;Kisteman LN;Isaacs JT
通讯作者：
Isaacs JT
影响因子：
10.3
作者：
Brennen, W. Nathaniel;Rosen, D. Marc;Denmeade, Samuel R.
通讯作者：
Denmeade, Samuel R.
影响因子：
6.6
作者：
Leibovich, BC;Cheville, JC;Blute, ML
通讯作者：
Blute, ML
影响因子：
4.2
作者：
Augoff, Katarzyna;Hryniewicz-Jankowska, Anita;Sikorski, Aleksander F.
通讯作者：
Sikorski, Aleksander F.