Abnormal development of kitten retino-geniculate connectivity in the absence of action potentials.
Abnormal development of kitten retino-geniculate connectivity in the absence of action potentials.
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在缺乏动作电位的情况下，小猫视网膜膝状体连接异常发育。
DOI：
10.1126/science.7100921
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发表时间：
1982
期刊：
影响因子：
56.9
通讯作者：
L. A. Stark
中科院分区：
文献类型：
--
作者：
S. Archer;M. Dubin;L. A. Stark
通过重复眼内注射河豚毒素5 ~ 8周，使新生小猫的一只眼睛的动作电位沉默。在河豚毒素阻断作用消失后，检查外侧膝状体中单个中继细胞的感受野特性。在接受治疗的眼睛的输入的层中发现的许多ON-OFF和双眼视野表明这些细胞具有极其异常的视网膜膝状体突触连接。这些效果与剥夺养育后观察到的不沉默动作电位的效果不同。得出的结论是，缺乏动作电位活动导致中枢神经系统发育异常。
Action potentials were silenced in one eye of neonatal kittens by repeated intraocular injections of tetrodotoxin for 5 to 8 weeks. After tetrodotoxin blockade was allowed to wear off, receptive field properties of individual relay cells in the lateral geniculate nucleus were examined. The many ON-OFF and binocular fields found in the layers that receive input from the treated eye suggest that these cells had extremely abnormal retino-geniculate synaptic connections. These effects were different in kind from those seen after deprivation rearing that does not silence action potentials. Lack of action potential activity was concluded to lead to abnormal development in the central nervous system.
视觉神经发育。
影响因子：
24.8
作者：
Movshon,JA;VanSluyters,RC
通讯作者：
VanSluyters,RC
影响因子：
56.9
作者：
PURVES, D;LICHTMAN, JW
通讯作者：
LICHTMAN, JW