Somatotropic Axis, Pace of Life and Aging.
Somatotropic Axis, Pace of Life and Aging.
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DOI：
10.3389/fendo.2022.916139
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发表时间：
2022
影响因子：
5.2
通讯作者：
中科院分区：
文献类型：
--
作者：
遗传生长激素（GH）缺乏或GH抵抗的小鼠比在相同条件下不受限制地获得食物的正常兄弟姐妹活得更长。这些突变体寿命的延长与它们的健康寿命（无残疾和疾病的寿命）的延长以及衰老的延迟和/或减缓有关。重要的是，生长激素和与生长激素相关的性状与衰老和寿命的调节有关，在未被基因改变的小鼠和包括人类在内的其他哺乳动物中也是如此。现有证据表明，抑制生长激素信号对衰老的影响是由多种相互作用机制介导的，涉及生长、繁殖和寿命之间的权衡。长寿的gh相关突变体的生活史特征包括出生后生长缓慢、性成熟延迟和繁殖力降低（产仔数减少和产仔间隔增加）。这些特征与较慢的生活节奏是一致的，这是在自然环境中长寿的野生动物物种的一个充分记录的特征。显然，较慢的生活节奏（或者至少是它的一些特征）与物种内部和物种之间的寿命延长有关。这种关联是出乎意料的，可能看起来违反直觉，因为成年体型（一种依赖gh的特征）与物种内部和物种之间的寿命之间的关系是相反的，而不是相似的。需要对生命不同阶段的能量代谢和营养依赖信号通路进行研究，以阐明这些关系的机制。
Mice with genetic growth hormone (GH) deficiency or GH resistance live much longer than their normal siblings maintained under identical conditions with unlimited access to food. Extended longevity of these mutants is associated with extension of their healthspan (period of life free of disability and disease) and with delayed and/or slower aging. Importantly, GH and GH-related traits have been linked to the regulation of aging and longevity also in mice that have not been genetically altered and in other mammalian species including humans. Avai+lable evidence indicates that the impact of suppressed GH signaling on aging is mediated by multiple interacting mechanisms and involves trade-offs among growth, reproduction, and longevity. Life history traits of long-lived GH-related mutants include slow postnatal growth, delayed sexual maturation, and reduced fecundity (smaller litter size and increased intervals between the litters). These traits are consistent with a slower pace-of-life, a well-documented characteristic of species of wild animals that are long-lived in their natural environment. Apparently, slower pace-of-life (or at least some of its features) is associated with extended longevity both within and between species. This association is unexpected and may appear counterintuitive, because the relationships between adult body size (a GH-dependent trait) and longevity within and between species are opposite rather than similar. Studies of energy metabolism and nutrient-dependent signaling pathways at different stages of the life course will be needed to elucidate mechanisms of these relationships.
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影响因子：
4.8
作者：
Coschigano, KT;Holland, AN;Kopchick, JJ
通讯作者：
Kopchick, JJ
影响因子：
5.7
作者：
Barrios, Monica R.;Campos, Viviane C.;Jesus, Amelia M. R.
通讯作者：
Jesus, Amelia M. R.
影响因子：
4.1
作者：
Brown-Borg HM
通讯作者：
Brown-Borg HM
DOI：
10.1016/j.ssmph.2021.100966
发表时间：
2021-12
期刊：
SSM - population health
影响因子：
--
作者：
Anderson NW;Zimmerman FJ
通讯作者：
Zimmerman FJ
DOI：
10.1073/pnas.111158898
发表时间：
2001-06-05
影响因子：
11.1
作者：
Flurkey, K;Papaconstantinou, J;Harrison, DE
通讯作者：
Harrison, DE