Hormonal control of aging in rodents: the somatotropic axis.
Hormonal control of aging in rodents: the somatotropic axis.
复制标题
DOI：
10.1016/j.mce.2008.07.001
复制
发表时间：
2009-02-05
影响因子：
4.1
通讯作者：
Brown-Borg HM
中科院分区：
文献类型：
--
作者：
Brown-Borg HM
有越来越多的文献集中在促生长轴和调节衰老和长寿。这些报告中的许多数据来自多种内分泌突变体，这些突变体表现出生长激素（GH）和胰岛素样生长因子I（IGF-1）升高或这些激素中的一种或两种缺乏。一般来说，自发性和基因工程GH和IGF-1缺陷都导致身材矮小，性成熟和年龄相关病理学发育延迟以及寿命延长。与此相反，高循环GH的特征包括更大的体型，青春期和生殖衰老，增加癌症发病率和寿命缩短时，与野生型动物与正常的血浆激素浓度。这一信息，沿着在多个其他物种中发现的信息，暗示这一合成代谢途径是动物长寿的主要调节器。
There is a growing body of literature focusing on the somatotropic axis and regulation of aging and longevity. Many of these reports derive data from multiple endocrine mutants, those that exhibit both elevated growth hormone (GH) and insulin-like growth factor I (IGF-1) or deficiencies in one or both of these hormones. In general, both spontaneous and genetically engineered GH and IGF-1 deficiencies have lead to small body size, delayed development of sexual maturation and age-related pathology, and life span extension. In contrast, characteristics of high circulating GH included larger body sizes, early puberty and reproductive senescence, increased cancer incidence and reduced life span when compared to wild-type animals with normal plasma hormone concentrations. This information, along with that found in multiple other species, implicates this anabolic pathway as the major regulator of longevity in animals.
登录
查看更多内容
DOI：
10.1093/gerona/61.6.562
发表时间：
2006-06-01
影响因子：
5.1
作者：
Bonkowski, MS;Pamenter, RW;Bartke, A
通讯作者：
Bartke, A
影响因子：
4.8
作者：
Al-Regaiey, KA;Masternak, MM;Bartke, A
通讯作者：
Bartke, A
DOI：
10.1007/s11357-001-0012-6
发表时间：
2001-07-01
期刊：
JOURNAL OF THE AMERICAN AGING ASSOCIATION
影响因子：
--
作者：
Brown-Borg, H;Johnson, WT;Romanick, M
通讯作者：
Romanick, M
影响因子：
3.9
作者：
Brown-Borg, HM;Rakoczy, SG
通讯作者：
Rakoczy, SG
影响因子：
6.1
作者：
Balbis, A;Bartke, A;Turyn, D
通讯作者：
Turyn, D