Functional impairment, disability, and frailty in adults aging with HIV-infection.

Functional impairment, disability, and frailty in adults aging with HIV-infection.
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DOI:
10.1007/s11904-014-0215-y
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发表时间:
2014-09
影响因子:
4.6
通讯作者:
Campbell, Thomas B.
Campbell, Thomas B.
中科院分区:
医学2区
文献类型:
--
作者:
Erlandson, Kristine M.;Schrack, Jennifer A.;Jankowski, Catherine M.;Brown, Todd T.;Campbell, Thomas B.

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将抗逆转录病毒疗法(即ART)纳入艾滋病毒护理大大延长了艾滋病毒感染者的预期寿命。然而,与类似的未感染艾滋病毒的人群相比,艾滋病毒感染者的发病率和死亡率较高,并伴有早发性衰老并发症,包括神经认知能力下降、骨质疏松、身体功能受损、虚弱和跌倒。最近的共识指南鼓励临床医生和研究人员考虑艾滋病毒感染成人的功能损伤,作为了解衰老对一系列能力影响的一种措施。尽管评估艾滋病毒感染老年人的功能很重要,但缺乏一致的术语和标准化的评估工具限制了功能评估在临床或研究环境中的应用。在此,我们区分了用于评估功能的不同方法,描述了老年HIV人群中已知的功能,并考虑了未来的研究方向。
The integration of antiretroviral therapy (i.e., ART) into HIV care has dramatically extended the life expectancy of those living with HIV. However, in comparison to similar HIV-uninfected populations, HIV-infected persons experience an excess of morbidity and mortality with an early onset of aging complications including neurocognitive decline, osteoporosis, impaired physical function, frailty, and falls. Recent consensus guidelines encourage clinicians and researchers to consider functional impairment of HIV-infected adults as a measure to understand the impact of aging across a range of abilities. Despite the importance of assessing function in persons aging with HIV infection, a lack of consistent terminology and standardization of assessment tools has limited the application of functional assessments in clinical or research settings. Herein, we distinguish between different approaches used to assess function, describe what is known about function in the aging HIV population, and consider directions for future research.
HIV 感染者慢性咳嗽和肺功能与 6 分钟步行测试表现的关系。
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