Polygenic risk scoring of human embryos: a qualitative study of media coverage.
Polygenic risk scoring of human embryos: a qualitative study of media coverage.
复制标题
DOI：
10.1186/s12910-021-00694-4
复制
发表时间：
2021-09-18
影响因子：
2.7
通讯作者：
Tšuiko O
中科院分区：
文献类型：
--
作者：
Pagnaer T;Siermann M;Borry P;Tšuiko O
目前的植入前基因测试(PGT)技术可以对整个基因组进行胚胎基因分型。这导致了人类胚胎多基因风险评分(PGT-P)的发展。最近实施的PGT-P，包括情报筛查，已被媒体和报道广泛报道，引发了重大争议。考虑到对辅助生殖日益增长的需求，我们评估了有关PGT-P的信息在新闻媒体中的传播方式，并探索了公共辩论中存在的伦理主题的多样性。检索LexisNexis学术数据库和Google News，检索有关多基因胚胎筛查的文章。这导致了新闻文章的出现。59篇原创文章符合入选标准。采用归纳内容分析法对这些文章进行分析。8.8%的文章对胚胎多基因评分给予正面描述，36.8%的文章表示负面态度。54.4%的人持中立态度，主要是强调该技术在体外受精环境中的实用价值有限。我们确定了五个主要的伦理主题，这些主题也出现在学术文献和关于生殖技术的更广泛的辩论中：对设计婴儿的滑坡、儿童和父母的福祉、对社会的影响、深思熟虑的选择和社会准备。胚胎多基因图谱的实施需要提出具体的建议。目前的媒体分析揭示了在为PGT-P制定未来指南时需要考虑的重要伦理主题。网上版载有补充材料，可在10.1186/s12910-021-00694-4查阅。
Current preimplantation genetic testing (PGT) technologies enable embryo genotyping across the whole genome. This has led to the development of polygenic risk scoring of human embryos (PGT-P). Recent implementation of PGT-P, including screening for intelligence, has been extensively covered by media reports, raising major controversy. Considering the increasing demand for assisted reproduction, we evaluated how information about PGT-P is communicated in press media and explored the diversity of ethical themes present in the public debate. LexisNexis Academic database and Google News were searched to identify articles about polygenic embryo screening. This led to 535 news articles. 59 original articles met the inclusion criteria. Inductive content analysis was used to analyse these articles. 8.8% of articles gave embryo polygenic scoring a positive portrayal, while 36.8% expressed a negative attitude. 54.4% were neutral, mostly highlighting limited practical value of the technology in in vitro fertilization settings. We identified five main ethical themes that are also present in academic literature and the broader debate on reproductive technologies: a slippery slope towards designer babies, well-being of the child and parents, impact on society, deliberate choice and societal readiness. Implementation of embryo polygenic profiling engenders a need for specific recommendations. Current media analysis discloses important ethical themes to consider when creating future guidelines for PGT-P. The online version contains supplementary material available at 10.1186/s12910-021-00694-4.
登录
查看更多内容
影响因子：
3.2
作者：
Hsieh, HF;Shannon, SE
通讯作者：
Shannon, SE
影响因子：
16.6
作者：
Duncan, L.;Shen, H.;Domingue, B.
通讯作者：
Domingue, B.
影响因子：
6.7
作者：
通讯作者：
--
影响因子：
8.3
作者：
Carvalho, Filipa;Moutou, Celine;De Rycke, Martine
通讯作者：
De Rycke, Martine
影响因子：
0.8
作者：
Duguet, Anne-Marie;Boyer-Beviere, Benedicte
通讯作者：
Boyer-Beviere, Benedicte