Lipid Droplets: A Key Cellular Organelle Associated with Cancer Cell Survival under Normoxia and Hypoxia.
Lipid Droplets: A Key Cellular Organelle Associated with Cancer Cell Survival under Normoxia and Hypoxia.
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DOI：
10.3390/ijms17091430
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发表时间：
2016-08-31
影响因子：
5.6
通讯作者：
Miyagi Y
中科院分区：
文献类型：
--
作者：
Koizume S;Miyagi Y
瓦尔堡效应描述了癌细胞甚至在常氧（O2充足）条件下从糖酵解获得能量的现象。由于低效和异常的脉管系统，肿瘤组织通常暴露于缺氧。癌细胞具有多种分子机制，通过重新编程细胞代谢来适应这种应激条件。缺氧诱导因子是肿瘤细胞缺氧诱导的主要转录因子，参与肿瘤细胞的代谢变化。此外，缺氧肿瘤区域内的癌细胞对血清组分如营养素和脂质的获取减少。然而，在肿瘤缺氧的情况下，这种血清因子剥夺对癌细胞生物学的影响尚未完全了解。癌细胞在常氧和缺氧下富含脂质，导致细胞器脂滴（LD）的产生增加。近年来，LD介导的癌细胞应激反应机制已被揭示。本文综述了LD在不同类型癌细胞中的产生和功能，以及与细胞环境因素（包括组织氧合状态和代谢机制）的关系。这些信息将有助于目前对癌细胞如何适应不同肿瘤环境以促进其存活的理解。
The Warburg effect describes the phenomenon by which cancer cells obtain energy from glycolysis even under normoxic (O2-sufficient) conditions. Tumor tissues are generally exposed to hypoxia owing to inefficient and aberrant vasculature. Cancer cells have multiple molecular mechanisms to adapt to such stress conditions by reprogramming the cellular metabolism. Hypoxia-inducible factors are major transcription factors induced in cancer cells in response to hypoxia that contribute to the metabolic changes. In addition, cancer cells within hypoxic tumor areas have reduced access to serum components such as nutrients and lipids. However, the effect of such serum factor deprivation on cancer cell biology in the context of tumor hypoxia is not fully understood. Cancer cells are lipid-rich under normoxia and hypoxia, leading to the increased generation of a cellular organelle, the lipid droplet (LD). In recent years, the LD-mediated stress response mechanisms of cancer cells have been revealed. This review focuses on the production and functions of LDs in various types of cancer cells in relation to the associated cellular environment factors including tissue oxygenation status and metabolic mechanisms. This information will contribute to the current understanding of how cancer cells adapt to diverse tumor environments to promote their survival.
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影响因子：
19
作者：
Ackerman, Daniel;Simon, M. Celeste
通讯作者：
Simon, M. Celeste
影响因子：
--
作者：
Eldeeb MA;Fahlman RP
通讯作者：
Fahlman RP
Warburg效应决定了丁酸酯介导的组蛋白乙酰化和细胞增殖的机制。
影响因子：
16
作者：
Donohoe, Dallas R.;Collins, Leonard B.;Wali, Aminah;Bigler, Rebecca;Sun, Wei;Bultman, Scott J.
通讯作者：
Bultman, Scott J.
影响因子：
4.3
作者：
Baenke F;Peck B;Miess H;Schulze A
通讯作者：
Schulze A
影响因子：
64.5
作者：
Bailey AP;Koster G;Guillermier C;Hirst EM;MacRae JI;Lechene CP;Postle AD;Gould AP
通讯作者：
Gould AP