Post-Acute COVID-19 Respiratory Symptoms in Patients With Asthma: An Electronic Health Records-Based Study.
Post-Acute COVID-19 Respiratory Symptoms in Patients With Asthma: An Electronic Health Records-Based Study.
复制标题
DOI：
10.1016/j.jaip.2022.12.003
复制
发表时间：
2023-03
影响因子：
9.4
通讯作者：
Zhou, Li
中科院分区：
文献类型：
--
作者：
Wang, Liqin;Foer, Dinah;Zhang, Yuqing;Karlson, Elizabeth W.;Bates, David W.;Zhou, Li
病毒感染后呼吸道症状在哮喘患者中很常见。急性COVID-19后的呼吸道症状在普通人群中被广泛报道，但缺乏确定哮喘患者症状风险的大规模研究。确定并比较哮喘患者和非哮喘患者发生急性COVID-19后呼吸道症状的风险。这项回顾性观察性队列研究纳入了2020年3月4日至2021年1月20日期间的COVID-19阳性患者，在美国东北部的医疗保健系统中进行了长达180天的医疗保健随访。使用自然语言处理提取COVID-19诊断后第28天至180天临床记录中记录的呼吸道症状。根据急性COVID-19期间的住院状态对队列进行分层。单变量和多变量分析用于比较哮喘患者和非哮喘患者的症状，调整人口统计学和临床混杂因素。在31,084名符合条件的COVID-19患者中，2863名（9.2%）在急性COVID-19期间住院; 4049名（13.0%）有哮喘病史，占住院患者的13.8%，占非住院患者的12.9%。在COVID-19急性期后，哮喘患者发生呼吸短促、咳嗽、支气管痉挛和喘息的风险显著高于无哮喘病史的患者。哮喘患者的支气管痉挛和喘息等呼吸道症状发生率也较高。在急性COVID-19期间未住院的哮喘患者咳嗽、呼吸异常、痰液变化和更广泛的呼吸道症状的风险也更高。在COVID-19导致这一人群的意识和监测增加后，哮喘患者可能对呼吸道症状的负担认识不足。
Post-viral respiratory symptoms are common among patients with asthma. Respiratory symptoms after acute COVID-19 are widely reported in the general population, but large-scale studies identifying symptom risk for patients with asthma are lacking. To identify and compare risk for post–acute COVID-19 respiratory symptoms in patients with and without asthma. This retrospective, observational cohort study included COVID-19–positive patients between March 4, 2020, and January 20, 2021, with up to 180 days of health care follow-up in a health care system in the Northeastern United States. Respiratory symptoms recorded in clinical notes from days 28 to 180 after COVID-19 diagnosis were extracted using natural language processing. Cohorts were stratified by hospitalization status during the acute COVID-19 period. Univariable and multivariable analyses were used to compare symptoms among patients with and without asthma adjusting for demographic and clinical confounders. Among 31,084 eligible patients with COVID-19, 2863 (9.2%) had hospitalization during the acute COVID-19 period; 4049 (13.0%) had a history of asthma, accounting for 13.8% of hospitalized and 12.9% of nonhospitalized patients. In the post–acute COVID-19 period, patients with asthma had significantly higher risk of shortness of breath, cough, bronchospasm, and wheezing than patients without an asthma history. Incident respiratory symptoms of bronchospasm and wheezing were also higher in patients with asthma. Patients with asthma who had not been hospitalized during acute COVID-19 had additionally higher risk of cough, abnormal breathing, sputum changes, and a wider range of incident respiratory symptoms. Patients with asthma may have an under-recognized burden of respiratory symptoms after COVID-19 warranting increased awareness and monitoring in this population.
登录
查看更多内容
COVID-19 的 50 多种长期影响：系统回顾和荟萃分析。
影响因子：
4.6
作者：
Lopez-Leon S;Wegman-Ostrosky T;Perelman C;Sepulveda R;Rebolledo PA;Cuapio A;Villapol S
通讯作者：
Villapol S
成人共卷199岁和≥65岁的成人共同条件 - 2020年3月至2021年11月，美国
DOI：
10.15585/mmwr.mm7121e1
发表时间：
2022-05-27
期刊：
Morbidity and Mortality Weekly Report
影响因子：
--
作者：
通讯作者：
--
影响因子：
13.8
作者：
Bellan M;Soddu D;Balbo PE;Baricich A;Zeppegno P;Avanzi GC;Baldon G;Bartolomei G;Battaglia M;Battistini S;Binda V;Borg M;Cantaluppi V;Castello LM;Clivati E;Cisari C;Costanzo M;Croce A;Cuneo D;De Benedittis C;De Vecchi S;Feggi A;Gai M;Gambaro E;Gattoni E;Gramaglia C;Grisafi L;Guerriero C;Hayden E;Jona A;Invernizzi M;Lorenzini L;Loreti L;Martelli M;Marzullo P;Matino E;Panero A;Parachini E;Patrucco F;Patti G;Pirovano A;Prosperini P;Quaglino R;Rigamonti C;Sainaghi PP;Vecchi C;Zecca E;Pirisi M
通讯作者：
Pirisi M
影响因子：
4.5
作者：
Lybarger K;Ostendorf M;Thompson M;Yetisgen M
通讯作者：
Yetisgen M
影响因子：
64.8
作者：
Al-Aly, Ziyad;Xie, Yan;Bowe, Benjamin
通讯作者：
Bowe, Benjamin