1,4-Butanediol as a reducing agent in transfer hydrogenation reactions.
1,4-Butanediol as a reducing agent in transfer hydrogenation reactions.
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1,4-丁二醇作为转移氢化反应中的还原剂。
DOI：
10.1002/asia.200900527
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Jonathan M. J. Williams
中科院分区：
文献类型：
--
作者：
H. Maytum;J. Francos;David J. Whatrup;Jonathan M. J. Williams
1，4-丁二醇能够在氢转移反应中向酮、亚胺和烯烃提供两当量的H（2）。与在酮的还原中建立平衡的简单醇不同，1，4-丁二醇由于丁内酯的形成而基本上不可逆地起作用，丁内酯充当热力学汇。因此，不需要使用非常过量的1，4-丁二醇来实现还原反应。此外，烯丙醇通过异构化/还原顺序使用钌催化剂与1，4-丁二醇作为还原剂被还原成饱和醇。亚胺和烯烃也在类似条件下被还原。
1,4-Butanediol is able to deliver two equivalents of H(2) in hydrogen-transfer reactions to ketones, imines, and alkenes. Unlike simple alcohols, which establish equilibrium in the reduction of ketones, 1,4-butanediol acts essentially irreversibly owing to the formation of butyrolactone, which acts as a thermodynamic sink. It is therefore not necessary to use 1,4-butanediol in great excess in order to achieve reduction reactions. In addition, allylic alcohols are reduced to saturated alcohols through an isomerization/reduction sequence using a ruthenium catalyst with 1,4-butanediol as the reducing agent. Imines and alkenes are also reduced under similar conditions.
影响因子：
4
作者：
Nixon, Tracy D.;Whittlesey, Michael K.;Williams, Jonathan M. J.
通讯作者：
Williams, Jonathan M. J.