Targeting the hallmarks of aging to improve influenza vaccine responses in older adults.
Targeting the hallmarks of aging to improve influenza vaccine responses in older adults.
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针对衰老的标志，以改善老年人的流感疫苗反应。
DOI：
10.1186/s12979-023-00348-6
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发表时间：
2023-05-17
期刊：
影响因子：
--
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与艾滋病相关的免疫反应下降对以后的生活中对抗疾病构成了挑战。流感（流感）感染仍然是老年人的一个重大负担，往往会导致感染后幸存者的灾难性残疾。尽管有专门为老年人设计的疫苗，但流感的负担仍然很高，总体流感疫苗的有效性在这一人群中仍然不足。最近的老年科学研究强调了针对生物衰老以改善多种年龄相关衰退的实用性。事实上，对疫苗接种的反应是高度协调的，老年人的反应减弱可能不是由于单一的缺陷，而是由于多种与年龄相关的下降。在这篇综述中，我们强调了老年人疫苗反应的缺陷和潜在的老年科学指导的方法来克服这些缺陷。更具体地说，我们提出针对衰老特征的替代疫苗平台和干预措施，包括炎症，细胞衰老，微生物组紊乱和线粒体功能障碍，可能会改善老年人的疫苗反应和整体免疫恢复力。阐明增强疫苗免疫保护的新干预措施和方法对于最大限度地减少流感和其他传染病对老年人的不成比例影响至关重要。
Age-related declines in immune response pose a challenge in combating diseases later in life. Influenza (flu) infection remains a significant burden on older populations and often results in catastrophic disability in those who survive infection. Despite having vaccines designed specifically for older adults, the burden of flu remains high and overall flu vaccine efficacy remains inadequate in this population. Recent geroscience research has highlighted the utility in targeting biological aging to improve multiple age-related declines. Indeed, the response to vaccination is highly coordinated, and diminished responses in older adults are likely not due to a singular deficit, but rather a multitude of age-related declines. In this review we highlight deficits in the aged vaccine responses and potential geroscience guided approaches to overcome these deficits. More specifically, we propose that alternative vaccine platforms and interventions that target the hallmarks of aging, including inflammation, cellular senescence, microbiome disturbances, and mitochondrial dysfunction, may improve vaccine responses and overall immunological resilience in older adults. Elucidating novel interventions and approaches that enhance immunological protection from vaccination is crucial to minimize the disproportionate effect of flu and other infectious diseases on older adults.
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影响因子：
5.5
作者：
Allen JC;Toapanta FR;Chen W;Tennant SM
通讯作者：
Tennant SM
影响因子：
6.3
作者：
Cruz-Jentoft, Alfonso J.;Carpena-Ruiz, Marina;Sanchez-Garcia, Elisabet
通讯作者：
Sanchez-Garcia, Elisabet
DOI：
10.1146/annurev-pathol-121808-102144
发表时间：
2010
期刊：
Annual review of pathology
影响因子：
--
作者：
Coppé JP;Desprez PY;Krtolica A;Campisi J
通讯作者：
Campisi J
影响因子：
7.8
作者：
Briceno, Olivia;Lissina, Anna;Appay, Victor
通讯作者：
Appay, Victor
DOI：
10.1056/nejmoa2035389
发表时间：
2021-02-04
期刊：
The New England journal of medicine
影响因子：
--
作者：
Baden LR;El Sahly HM;Essink B;Kotloff K;Frey S;Novak R;Diemert D;Spector SA;Rouphael N;Creech CB;McGettigan J;Khetan S;Segall N;Solis J;Brosz A;Fierro C;Schwartz H;Neuzil K;Corey L;Gilbert P;Janes H;Follmann D;Marovich M;Mascola J;Polakowski L;Ledgerwood J;Graham BS;Bennett H;Pajon R;Knightly C;Leav B;Deng W;Zhou H;Han S;Ivarsson M;Miller J;Zaks T;COVE Study Group
通讯作者：
COVE Study Group