Understanding immunosenescence and its impact on vaccination of older adults.
Understanding immunosenescence and its impact on vaccination of older adults.
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DOI：
10.1016/j.vaccine.2020.11.002
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发表时间：
2020-12-14
期刊：
影响因子：
5.5
通讯作者：
Tennant SM
中科院分区：
文献类型：
--
作者：
Allen JC;Toapanta FR;Chen W;Tennant SM
老年人更容易受到病毒和细菌感染，感染性疾病的发病率和严重程度更高。虽然疫苗接种是预防传染病最合理的解决方案，但年龄≥65岁的个体的初次疫苗应答无法产生完全保护。这可能是由于免疫衰老，一个描述与免疫系统和自然年龄增长相关的功能差异的术语。先天性和适应性免疫系统都经历了与年龄相关的损伤，导致接种疫苗后保护不足。本文综述了目前对影响疫苗反应性的年龄相关变化的认识，包括先天细胞功能的缺陷、体液和细胞介导的免疫反应减弱、老年人当前的疫苗接种时间表，并总结了提高该年龄组疫苗有效性的潜在策略。由于年龄相关的免疫力下降和疫苗反应差，传染病仍然是老年人口的负担。
Older adults are more susceptible to viral and bacterial infection, and experience higher incidence and severity of infectious diseases. Although vaccination is the most logical solution in preventing infectious diseases, primary vaccine responses in individuals aged ≥65 years-old fail to generate complete protection. This is presumably attributed to immunosenescence, a term that describes functional differences associated with the immune system and natural age advancement. Both the innate and adaptive immune systems experience age-related impairments that contribute to insufficient protection following vaccination. This review addresses current knowledge of age-related changes that affect vaccine responsiveness; including the deficits in innate cell functions, dampened humoral and cell-mediated immune responses, current vaccination schedules for older adults, and concludes with potential strategies for improving vaccine efficacy specifically for this age group. Due to an age-related decline in immunity and poor vaccine responses, infectious diseases remain a burden among the aged population.
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影响因子：
3.7
作者：
Bodnar, AG;Kim, NW;Chiu, CP
通讯作者：
Chiu, CP
影响因子：
7.8
作者：
Briceno, Olivia;Lissina, Anna;Appay, Victor
通讯作者：
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影响因子：
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作者：
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DOI：
10.1038/nri3567
发表时间：
2014-01
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
通讯作者：
--
DOI：
10.1016/0167-5699(96)80543-3
发表时间：
1996-06-01
期刊：
IMMUNOLOGY TODAY
影响因子：
--
作者：
George, AJT;Ritter, MA
通讯作者：
Ritter, MA