Molecular microbiological methods in the diagnosis of neonatal sepsis.
Molecular microbiological methods in the diagnosis of neonatal sepsis.
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DOI：
10.1586/eri.10.89
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发表时间：
2010-09
影响因子：
5.7
通讯作者：
Versalovic J
中科院分区：
文献类型：
--
作者：
Venkatesh M;Flores A;Luna RA;Versalovic J
Neonatal sepsis is a major cause of neonatal mortality and morbidity. The current gold standard for diagnosis of sepsis, namely blood culture, suffers from low sensitivity and a reporting delay of approximately 48–72 h. Rapid detection of sepsis and institution of antimicrobial therapy may improve patient outcomes. Rapid and sensitive tests that can inform clinicians regarding the institution or optimization of antimicrobial therapy are urgently needed. The ideal diagnostic test should have adequate specificity and negative predictive value to reliably exclude sepsis and avoid unnecessary antibiotic therapy. We comprehensively searched for neonatal studies that evaluated molecular methods for diagnosis of sepsis. We identified 19 studies that were assessed with respect to assay methodology and diagnostic characteristics. In addition, we also reviewed newer molecular microbiological assays of relevance that have not been fully evaluated in neonates. Molecular methods offer distinct advantages over blood cultures, including increased sensitivity and rapid diagnosis. However, diagnostic accuracy and cost–effectiveness should be established before implementation in clinical practice.
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DOI：
10.1007/978-1-60327-999-4_7
发表时间：
2009-01-01
期刊：
MOLECULAR EPIDEMIOLOGY OF MICROORGANISMS
影响因子：
--
作者：
Ecker, David J.;Massire, Christian;Sampath, Rangarajan
通讯作者：
Sampath, Rangarajan
影响因子：
8.8
作者：
Chan, Kathy Y. Y.;Lam, Hugh S.;Ng, Pak C.
通讯作者：
Ng, Pak C.
影响因子：
9.4
作者：
Jordan, JA;Durso, MB
通讯作者：
Durso, MB
影响因子：
9.4
作者：
Cleven, Berit E. E.;Palka-Santini, Maria;Krut, Oleg
通讯作者：
Krut, Oleg
影响因子：
2.8
作者：
Evertsson, U;Monstein, HJ;Johansson, AG
通讯作者：
Johansson, AG