Transcriptomic Signatures of Airway Epithelium Infected With SARS-CoV-2: A Balance Between Anti-infection and Virus Load.
Transcriptomic Signatures of Airway Epithelium Infected With SARS-CoV-2: A Balance Between Anti-infection and Virus Load.
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DOI：
10.3389/fcell.2021.735307
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发表时间：
2021
影响因子：
5.5
通讯作者：
Song J
中科院分区：
文献类型：
--
作者：
Meng L;Qin H;Zhao J;He S;Wei Q;Wang Z;Shen J;Sooranna S;Song J
COVID-19 肺炎需要有效的药物治疗。然而，找到不仅能抑制病毒复制，还能抑制伴随的细胞因子风暴并维持适当的免疫反应的治疗药物是一个挑战。在本研究中，采用生物信息学分析方法系统评估了 SARS-CoV-2 对 COVID-19 患者肺上皮细胞基因表达的影响。发现了旁观者（暴露但未感染）和感染细胞特有的转录组表达，并通过对 COVID-19 感染的基因特征与疾病严重程度之间的关系进行差异表达基因分析来确定重要途径。我们发现，高病毒载量并不一定意味着上皮细胞反应低或疾病恢复不良。区分病毒相关基因作用的能力有助于开发针对 COVID-19 感染的潜在新药和疗法。
COVID-19 pneumonia requires effective medical therapies. However, it is a challenge to find therapeutic drugs that not only inhibit viral replication, but also inhibit the accompanying cytokine storm and maintain an appropriate immune response. In this study, the effects of SARS-CoV-2 on gene expression in lung epithelial cells from patients with COVID-19 were systematically evaluated with bioinformatics analysis methods. Transcriptome expression specific to bystander (exposed but uninfected) and infected cells were found, and the vital pathways were identified by conducting differentially expressed gene analysis regarding the relationship between gene signatures of COVID-19 infection and disease severity. We found that a high viral load did not necessarily imply a low response of epithelial cells or a poor disease convalescence. The ability to distinguish the role of virus-correlated genes facilitates the development of potential new medicines and therapies for COVID-19 infection.
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影响因子：
44.1
作者：
Wauters E;Van Mol P;Garg AD;Jansen S;Van Herck Y;Vanderbeke L;Bassez A;Boeckx B;Malengier-Devlies B;Timmerman A;Van Brussel T;Van Buyten T;Schepers R;Heylen E;Dauwe D;Dooms C;Gunst J;Hermans G;Meersseman P;Testelmans D;Yserbyt J;Tejpar S;De Wever W;Matthys P;CONTAGIOUS collaborators;Neyts J;Wauters J;Qian J;Lambrechts D
通讯作者：
Lambrechts D
影响因子：
17.1
作者：
Hoepel W;Chen HJ;Geyer CE;Allahverdiyeva S;Manz XD;de Taeye SW;Aman J;Mes L;Steenhuis M;Griffith GR;Bonta PI;Brouwer PJM;Caniels TG;van der Straten K;Golebski K;Jonkers RE;Larsen MD;Linty F;Nouta J;van Roomen CPAA;van Baarle FEHP;van Drunen CM;Wolbink G;Vlaar APJ;de Bree GJ;Sanders RW;Willemsen L;Neele AE;van de Beek D;Rispens T;Wuhrer M;Bogaard HJ;van Gils MJ;Vidarsson G;de Winther M;den Dunnen J
通讯作者：
den Dunnen J
影响因子：
4.1
作者：
Meng Y;Cai K;Zhao J;Huang K;Ma X;Song J;Liu Y
通讯作者：
Liu Y
影响因子：
50.3
作者：
Sun Y;Zhou B;Mao F;Xu J;Miao H;Zou Z;Phuc Khoa LT;Jang Y;Cai S;Witkin M;Koche R;Ge K;Dressler GR;Levine RL;Armstrong SA;Dou Y;Hess JL
通讯作者：
Hess JL
影响因子：
9.3
作者：
Steuerman Y;Cohen M;Peshes-Yaloz N;Valadarsky L;Cohn O;David E;Frishberg A;Mayo L;Bacharach E;Amit I;Gat-Viks I
通讯作者：
Gat-Viks I