HIV-1(LAI) Nef blocks the development of hematopoietic stem/progenitor cells into myeloid-erythroid lineage cells.
HIV-1(LAI) Nef blocks the development of hematopoietic stem/progenitor cells into myeloid-erythroid lineage cells.
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DOI：
10.1186/s13062-021-00317-3
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发表时间：
2021-12-20
期刊：
影响因子：
5.5
通讯作者：
Fu X
中科院分区：
文献类型：
--
作者：
Zou W;Xing J;Zou S;Jiang M;Chen X;Chen Q;Liu D;Zhang X;Fu X
尽管进行了抗病毒治疗，但人类免疫缺陷病毒-1(HIV-1)感染者经常出现各种造血异常，但其潜在机制仍不清楚。Nef在HIV-1诱导的T细胞丢失和疾病进展中起重要作用，但目前尚不清楚Nef是否参与了与感染相关的其他造血异常。在本研究中，我们研究了HIV-1LAI Nef(LaI Nef)对造血干/祖细胞(HSPC)向髓系红系细胞发育的影响，发现在体外和由表达nef的HSPC重组的人源化小鼠中，Nef的表达都抑制了HSPC的分化。我们的新发现表明，Lai Nef损害了髓系-红系细胞的发育，针对Nef的治疗将有望在纠正HIV-1相关的造血异常方面发挥作用。网上版载有补充材料，可在10.1186/s13062-021-00317-3查阅。
A variety of hematopoietic abnormalities are commonly seen in human immunodeficiency virus-1 (HIV-1) infected individuals despite antiviral therapy, but the underlying mechanism remains elusive. Nef plays an important role in HIV-1 induced T cell loss and disease progression, but it is not known whether Nef participates in other hematopoietic abnormalities associated with infection. In the current study we investigated the influence of HIV-1LAI Nef (LAI Nef) on the development of hematopoietic stem/progenitor cells (HSPCs) into myeloid-erythroid lineage cells, and found that nef expression in HSPCs blocked their differentiation both in vitro and in humanized mice reconstituted with nef-expressing HSPCs. Our novel findings demonstrate LAI Nef compromised the development of myeloid-erythroid lineage cells, and therapeutics targeting Nef would be promising in correcting HIV-1 associated hematopoietic abnormalities. The online version contains supplementary material available at 10.1186/s13062-021-00317-3.
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DOI：
10.1111/j.1600-0854.2009.01006.x
发表时间：
2010-01
期刊：
Traffic (Copenhagen, Denmark)
影响因子：
--
作者：
Lenassi M;Cagney G;Liao M;Vaupotic T;Bartholomeeusen K;Cheng Y;Krogan NJ;Plemenitas A;Peterlin BM
通讯作者：
Peterlin BM
影响因子：
6.4
作者：
McNamara RP;Costantini LM;Myers TA;Schouest B;Maness NJ;Griffith JD;Damania BA;MacLean AG;Dittmer DP
通讯作者：
Dittmer DP
影响因子：
20.3
作者：
Nixon, Christopher C.;Vatakis, Dimitrios N.;Zack, Jerome A.
通讯作者：
Zack, Jerome A.
影响因子：
23.9
作者：
Mazumdar C;Shen Y;Xavy S;Zhao F;Reinisch A;Li R;Corces MR;Flynn RA;Buenrostro JD;Chan SM;Thomas D;Koenig JL;Hong WJ;Chang HY;Majeti R
通讯作者：
Majeti R
影响因子：
1.5
作者：
Ali, Syed A.;Huang, Ming-Bo;Bond, Vincent C.
通讯作者：
Bond, Vincent C.