Pharmacological inhibition of feline immunodeficiency virus (FIV).
Pharmacological inhibition of feline immunodeficiency virus (FIV).
复制标题
DOI：
10.3390/v4050708
复制
发表时间：
2012-05
期刊：
影响因子：
--
通讯作者：
Bienzle D
中科院分区：
文献类型：
--
作者：
Mohammadi H;Bienzle D
猫免疫缺陷病毒（FIV）是逆转录病毒科病毒家族的成员，并且在全世界的家猫和非家猫中引起获得性免疫缺陷综合征（AIDS）。FIV的基因组结构和由该病毒引起的疾病的临床特征与人类免疫缺陷病毒（HIV）相似。两种病毒都感染T淋巴细胞、单核细胞和巨噬细胞，它们在感染细胞中的复制周期是类似的。由于FIV和HIV在基因组组织、病毒结构、病毒复制和疾病发病机制方面具有显著的相似性，因此FIV感染猫是研究和开发针对HIV的新型药物和疫苗的有用工具。在HIV感染中广泛研究的抗逆转录病毒药物针对病毒复制周期的不同步骤：（1）在与宿主细胞表面受体和共受体的附着水平上抑制病毒进入易感细胞;（2）抑制病毒膜与细胞膜的融合;（3）阻断病毒基因组RNA的逆转录;（4）中断核移位和病毒DNA整合到宿主基因组中;（5）阻止病毒转录物加工和核输出;（6）抑制病毒粒子组装和成熟。尽管抗逆转录病毒疗法在减缓人类疾病进展方面取得了很大的成功，但类似的疗法尚未在猫身上进行过彻底的研究。在这篇文章中，我们回顾了目前的药理学方法和抗慢病毒治疗的新目标，并严格评估潜在的适用于猫FIV感染。
Feline immunodeficiency virus (FIV) is a member of the retroviridae family of viruses and causes an acquired immunodeficiency syndrome (AIDS) in domestic and non-domestic cats worldwide. Genome organization of FIV and clinical characteristics of the disease caused by the virus are similar to those of human immunodeficiency virus (HIV). Both viruses infect T lymphocytes, monocytes and macrophages, and their replication cycle in infected cells is analogous. Due to marked similarity in genomic organization, virus structure, virus replication and disease pathogenesis of FIV and HIV, infection of cats with FIV is a useful tool to study and develop novel drugs and vaccines for HIV. Anti-retroviral drugs studied extensively in HIV infection have targeted different steps of the virus replication cycle: (1) inhibition of virus entry into susceptible cells at the level of attachment to host cell surface receptors and co-receptors; (2) inhibition of fusion of the virus membrane with the cell membrane; (3) blockade of reverse transcription of viral genomic RNA; (4) interruption of nuclear translocation and viral DNA integration into host genomes; (5) prevention of viral transcript processing and nuclear export; and (6) inhibition of virion assembly and maturation. Despite much success of anti-retroviral therapy slowing disease progression in people, similar therapy has not been thoroughly investigated in cats. In this article we review current pharmacological approaches and novel targets for anti-lentiviral therapy, and critically assess potentially suitable applications against FIV infection in cats.
登录
查看更多内容
影响因子：
16.8
作者：
de Parseval, A;Chatterji, U;Elder, JH
通讯作者：
Elder, JH
影响因子：
15
作者：
Becer, C. Remzi;Gibson, Matthew I.;Geng, Jin;Ilyas, Rebecca;Wallis, Russell;Mitchell, Daniel A.;Haddleton, David M.
通讯作者：
Haddleton, David M.
影响因子：
5.4
作者：
Egberink, HF;De Clercq, E;Schols, D
通讯作者：
Schols, D
影响因子：
2.7
作者：
Al-Abed, Y;Dubrovsky, L;Bukrinsky, M
通讯作者：
Bukrinsky, M
影响因子：
4.9
作者：
D'Cruz, OJ;Waurzyniak, B;Uckun, FM
通讯作者：
Uckun, FM