Pretreatment serum albumin as a predictor of cancer survival: a systematic review of the epidemiological literature.
Pretreatment serum albumin as a predictor of cancer survival: a systematic review of the epidemiological literature.
复制标题
DOI：
10.1186/1475-2891-9-69
复制
发表时间：
2010-12-22
影响因子：
5.4
通讯作者：
Lis CG
中科院分区：
文献类型：
--
作者：
Gupta D;Lis CG
有几种评估癌症营养状况的方法，其中血清白蛋白是最常用的方法之一。近年来，营养不良作为癌症患者生存预测因素的作用受到了相当大的关注。因此，研究血清白蛋白是否可作为癌症存活率的预后指标是合理的。本文综述了所有可用的流行病学文献之间的关联治疗前血清白蛋白水平和生存在不同类型的癌症。使用MEDLINE数据库（1995年1月至2010年6月）对文献进行系统检索，以确定血清白蛋白与癌症生存率之间关系的流行病学研究。要纳入审查，研究必须具有：以英语发表，报告了在患有任何类型癌症的人类中收集的数据，将血清白蛋白作为一个或唯一的预测因素，将生存率作为结局指标之一（主要或次要），并具有以下任何研究设计（病例对照、队列、横断面、病例系列前瞻性、回顾性、巢式病例对照、生态学、临床试验、荟萃分析）。在回顾的29项关于胃肠道癌症的研究中，除3项外，所有研究都发现在多变量分析中较高的血清白蛋白水平与较好的生存率相关。在回顾的10项关于肺癌的研究中，除一项外，所有研究都发现血清白蛋白水平较高与生存率较高相关。在6项关于女性癌症和多种癌症的研究中，血清白蛋白水平较低与生存率低相关。最后，在对其他癌症部位患者进行的所有8项研究中，血清白蛋白水平较低与生存率低相关。治疗前血清白蛋白水平提供了有用的癌症预后意义。因此，血清白蛋白水平可用于临床试验，以更好地确定癌症患者的基线风险。然而，证明因果关系的一个关键差距是缺乏临床试验证明通过静脉输注或高营养提高白蛋白水平可降低癌症死亡率的过度风险。
There are several methods of assessing nutritional status in cancer of which serum albumin is one of the most commonly used. In recent years, the role of malnutrition as a predictor of survival in cancer has received considerable attention. As a result, it is reasonable to investigate whether serum albumin has utility as a prognostic indicator of cancer survival in cancer. This review summarizes all available epidemiological literature on the association between pretreatment serum albumin levels and survival in different types of cancer. A systematic search of the literature using the MEDLINE database (January 1995 through June 2010) to identify epidemiologic studies on the relationship between serum albumin and cancer survival. To be included in the review, a study must have: been published in English, reported on data collected in humans with any type of cancer, had serum albumin as one of the or only predicting factor, had survival as one of the outcome measures (primary or secondary) and had any of the following study designs (case-control, cohort, cross-sectional, case-series prospective, retrospective, nested case-control, ecologic, clinical trial, meta-analysis). Of the 29 studies reviewed on cancers of the gastrointestinal tract, all except three found higher serum albumin levels to be associated with better survival in multivariate analysis. Of the 10 studies reviewed on lung cancer, all excepting one found higher serum albumin levels to be associated with better survival. In 6 studies reviewed on female cancers and multiple cancers each, lower levels of serum albumin were associated with poor survival. Finally, in all 8 studies reviewed on patients with other cancer sites, lower levels of serum albumin were associated with poor survival. Pretreatment serum albumin levels provide useful prognostic significance in cancer. Accordingly, serum albumin level could be used in clinical trials to better define the baseline risk in cancer patients. A critical gap for demonstrating causality, however, is the absence of clinical trials demonstrating that raising albumin levels by means of intravenous infusion or by hyperalimentation decreases the excess risk of mortality in cancer.
登录
查看更多内容
DOI：
10.1016/s0022-5223(99)70056-5
发表时间：
1999-11-01
影响因子：
6
作者：
Engelman, DT;Adams, DH;Rizzo, RJ
通讯作者：
Rizzo, RJ
影响因子：
--
作者：
Dixon, MR;Haukoos, JS;Stamos, MJ
通讯作者：
Stamos, MJ
影响因子：
3.7
作者：
Choi, Gi-Hong;Kim, Dong-Hyun;Kim, Byong-Ro
通讯作者：
Kim, Byong-Ro
DOI：
10.1016/j.ejon.2005.09.005
发表时间：
2005-01-01
期刊：
European journal of oncology nursing : the official journal of European Oncology Nursing Society
影响因子：
--
作者：
Davies, Michelle
通讯作者：
Davies, Michelle
影响因子：
2.9
作者：
Barber, MD;Ross, JA;Fearon, KCH
通讯作者：
Fearon, KCH