Communication between Toxoplasma gondii and its host: impact on parasite growth, development, immune evasion, and virulence.

Communication between Toxoplasma gondii and its host: impact on parasite growth, development, immune evasion, and virulence.
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Toxoplasma Gondii及其宿主之间的交流:对寄生虫生长,发育,免疫逃避和毒力的影响。

DOI:
10.1111/j.1600-0463.2009.02453.x
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发表时间:
2009-05
期刊:
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
影响因子:
--
通讯作者:
Saeij JP
Saeij JP
中科院分区:
其他
文献类型:
--
作者:
Blader IJ;Saeij JP

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弓形虫是一种专性细胞内原生动物寄生虫,可感染大多数温血动物,并在发育中的胎儿和免疫受损患者中引起严重和危及生命的疾病。虽然弓形虫是在100多年前发现的,但我们现在才开始认识到寄生虫对其宿主的调节对寄生虫生长、缓殖子发育、免疫逃避和毒力的重要性。本综述的目的是强调这些发现,建立弓形虫与其宿主之间的沟通的综合模型,并讨论这些研究中出现的新问题。
Toxoplasma gondii is an obligate intracellular protozoan parasite that can infect most warm-blooded animals and cause severe and life-threatening disease in developing fetuses and in immune-compromised patients. Although Toxoplasma was discovered over 100 years ago, we are only now beginning to appreciate the importance of the role that parasite modulation of its host has on parasite growth, bradyzoite development, immune evasion, and virulence. The goal of this review is to highlight these findings, to develop an integrated model for communication between Toxoplasma and its host, and to discuss new questions that arise out of these studies.
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