The role of disorder in interaction networks: a structural analysis.
The role of disorder in interaction networks: a structural analysis.
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疾病在交互网络中的作用：结构分析。
DOI：
10.1038/msb.2008.16
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发表时间：
2008
影响因子：
9.9
通讯作者：
Gerstein, Mark
中科院分区：
文献类型：
--
作者：
Kim, Philip M.;Sboner, Andrea;Xia, Yu;Gerstein, Mark
近期研究强调了在蛋白质网络的拓扑分析中纳入结构信息的价值。在此，我们利用结构信息来研究内在无序性在这些网络中的作用。枢纽蛋白往往比其他蛋白（即蛋白质组平均值）更无序；然而，我们发现这仅适用于具有一个或两个结合界面的蛋白（“单一”界面枢纽）。相比之下，多界面枢纽中无序残基的分布与整个蛋白质组并无差异。令人惊讶的是，我们发现单一界面枢纽的结合界面具有高度的结构性，多界面枢纽也是如此。然而，单一界面枢纽的结合伴侣往往比蛋白质组平均值具有更高程度的无序性，这表明它们结合的混杂性与其结合伴侣的无序性有关。反过来，单一界面枢纽较高程度的无序性可以部分地由它们倾向于在级联中相互结合来解释。在信号通路中，更具体地说在激酶级联中，可以发现这种趋势的一个很好的例证。最后，我们的研究结果对当前有关聚会枢纽和约会枢纽的争议具有启示意义。
Recent studies have emphasized the value of including structural information into the topological analysis of protein networks. Here, we utilized structural information to investigate the role of intrinsic disorder in these networks. Hub proteins tend to be more disordered than other proteins (i.e. the proteome average); however, we find this only true for those with one or two binding interfaces (‘single'-interface hubs). In contrast, the distribution of disordered residues in multi-interface hubs is indistinguishable from the overall proteome. Surprisingly, we find that the binding interfaces in single-interface hubs are highly structured, as is the case for multi-interface hubs. However, the binding partners of single-interface hubs tend to have a higher level of disorder than the proteome average, suggesting that their binding promiscuity is related to the disorder of their binding partners. In turn, the higher level of disorder of single-interface hubs can be partly explained by their tendency to bind to each other in a cascade. A good illustration of this trend can be found in signaling pathways and, more specifically, in kinase cascades. Finally, our findings have implications for the current controversy related to party and date-hubs.
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影响因子：
9.8
作者：
Batada NN;Reguly T;Breitkreutz A;Boucher L;Breitkreutz BJ;Hurst LD;Tyers M
通讯作者：
Tyers M
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作者：
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通讯作者：
Gerstein, Mark B.
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通讯作者：
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作者：
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通讯作者：
Russell, Robert B.